KEGG   REACTION: R06448
Entry
R06448                      Reaction                               
Definition
5 Methylmalonyl-CoA + 2 Malonyl-CoA + (2S)-Ethylmalonyl-CoA + 7 NADPH + 7 H+ <=> 8 CoA + Tylactone + 8 CO2 + 3 H2O + 7 NADP+
Equation
5 C02557 + 2 C00083 + C18026 + 7 C00005 + 7 C00080 <=> 8 C00010 + C12000 + 8 C00011 + 3 C00001 + 7 C00006
Comment
tylactone synthase,TylG1-5
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557  C00010_C18026
RC02829  C02557_C12000
RC02910  C02557_C12000
RC02911  C00083_C12000
RC02912  C00083_C12000
RC02914  C02557_C12000
RC02917  C02557_C12000
RC02919  C02557_C12000
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Orthology
K15988  tylactone synthase 1
K24555  tylactone synthase 2
K24556  tylactone synthase 3
K24557  tylactone synthase 4
K24558  tylactone synthase 5
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