REACTION: R06677
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Entry
R06677 Reaction
Name
auramycinone:NADP+ 7-oxidoreductase
Definition
Auraviketone + NADPH + H+ <=> Auramycinone + NADP+
Equation
C12417
+
C00005
+
C00080
<=>
C12419
+
C00006
Reaction class
RC00001
C00005_C00006
RC00234
C12417_C12419
Enzyme
1.1.1.362
Pathway
rn01057
Biosynthesis of type II polyketide products
rn01110
Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:
br08201
]
1. Oxidoreductase reactions
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.362
R06677 Auraviketone + NADPH + H+ <=> Auramycinone + NADP+
BRITE hierarchy
Orthology
K15944
nogalaviketone/aklaviketone reductase [EC:1.1.1.-
1.1.1.362
]
Reference
1 [PMID:
10658662
]
Authors
Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mantsala P
Title
Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
Journal
Microbiology 146 ( Pt 1):155-63 (2000)
DOI:
10.1099/00221287-146-1-155
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