KEGG   REACTION: R07052
Entry
R07052                      Reaction                               
Definition
Arachidonate + Oxygen + NADPH + H+ <=> 5,6-EET + NADP+ + H2O
Equation
C00219 + C00007 + C00005 + C00080 <=> C14768 + C00006 + C00001
Comment
CYP2C10/11/23/34/40, CYP2B, CYP2J2/4
Reaction class
RC00001  C00005_C00006
RC01711  C00219_C14768
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00590  Arachidonic acid metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R07052  Arachidonate + Oxygen + NADPH + H+ <=> 5,6-EET + NADP+ + H2O
    1.14.14.-
     R07052  Arachidonate + Oxygen + NADPH + H+ <=> 5,6-EET + NADP+ + H2O
Orthology
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07418  cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
Reference
1  [PMID:23362865]
  Authors
Knights KM, Rowland A, Miners JO.
  Title
Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).
  Journal
Br J Clin Pharmacol 76:587-602 (2013)
DOI:10.1111/bcp.12086
Reference
2  [PMID:11679404]
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
3  [PMID:10908295]
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
LinkDB

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