KEGG   REACTION: R08225
Entry
R08225                      Reaction                               
Definition
Tegafur + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5-FU + Succinic aldehyde + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C12673 + C03024 + C00007 <=> C07649 + C16835 + C03161 + C00001
Comment
CYP2A6
multi-step reaction
intermediate (5'-hydroxytegafur)
Reaction class
RC00063  C07649_C12673
RC02297  C12673_C16835
Enzyme
1.14.14.-
Pathway
rn00983  Drug metabolism - other enzymes
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     R08225  Tegafur + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5-FU + Succinic aldehyde + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K17683  cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
LinkDB

DBGET integrated database retrieval system