KEGG   REACTION: R08265
Entry
R08265                      Reaction                               
Definition
Morphine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Normorphine + Formaldehyde + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C01516 + C03024 + C00007 <=> C11785 + C00067 + C03161 + C00001
Comment
P450:N-demethylation
Reaction class
RC01198  C01516_C11785
RC02299  C00067_C01516
Enzyme
1.14.14.1
Pathway
rn00982  Drug metabolism - cytochrome P450
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R08265  Morphine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Normorphine + Formaldehyde + [Oxidized NADPH---hemoprotein reductase] + H2O
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