KEGG   REACTION: R08617
Entry
R08617                      Reaction                               
Name
D-glucose-6-phosphate phosphate-lyase (2-deoxy-scyllo-inosose-forming)
Definition
D-Glucose 6-phosphate <=> 2-Deoxy-scyllo-inosose + Orthophosphate
Equation
C00092 <=> C17209 + C00009
Comment
multi-step reaction
Reaction class
RC02334  C00092_C17209
Enzyme
4.2.3.124
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.124
     R08617  D-Glucose 6-phosphate <=> 2-Deoxy-scyllo-inosose + Orthophosphate
Orthology
K13546  2-deoxy-scyllo-inosose synthase [EC:4.2.3.124]
Reference
1  [PMID:17879343]
  Authors
Nango E, Kumasaka T, Hirayama T, Tanaka N, Eguchi T
  Title
Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+.
  Journal
Proteins 70:517-27 (2008)
DOI:10.1002/prot.21526
Other DBs
RHEA: 33074
LinkDB

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