KEGG   REACTION: R08770
Entry
R08770                      Reaction                               
Definition
4-Hydroxy-3-polyprenylbenzoate + Oxygen <=> 3,4-Dihydroxy-5-polyprenylbenzoate + H2O
Equation
C05848 + C00007 <=> C17554 + C00001
Comment
general reaction (see R06865, n=5-9)
Reaction class
RC00046  C05848_C17554
Enzyme
1.14.13.-
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00128  Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate + polyprenyl-PP => ubiquinol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R08770  4-Hydroxy-3-polyprenylbenzoate + Oxygen <=> 3,4-Dihydroxy-5-polyprenylbenzoate + H2O
Orthology
K06126  ubiquinone biosynthesis monooxygenase Coq6 [EC:1.14.13.-]
Reference
1  [PMID:21944752]
  Authors
Ozeir M, Muhlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F.
  Title
Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency.
  Journal
Chem Biol 18:1134-42 (2011)
DOI:10.1016/j.chembiol.2011.07.008
Reference
2  [PMID:26808124]
  Authors
Ismail A, Leroux V, Smadja M, Gonzalez L, Lombard M, Pierrel F, Mellot-Draznieks C, Fontecave M.
  Title
Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-Dependent Monooxygenase Coq6.
  Journal
PLoS Comput Biol 12:e1004690 (2016)
DOI:10.1371/journal.pcbi.1004690
Reference
3  [PMID:11583838]
  Authors
Meganathan R
  Title
Ubiquinone biosynthesis in microorganisms.
  Journal
FEMS Microbiol Lett 203:131-9 (2001)
DOI:10.1111/j.1574-6968.2001.tb10831.x
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