KEGG   REACTION: R08963
Entry
R08963                      Reaction                               
Name
androstan-3alpha,17beta-diol:NADP+ oxidoreductase
Definition
Androstan-3alpha,17beta-diol + NADP+ <=> Dihydrotestosterone + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00144  C03852_C03917
Enzyme
1.1.1.50        1.1.1.357
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50
     R08963  Androstan-3alpha,17beta-diol + NADP+ <=> Dihydrotestosterone + NADPH + H+
    1.1.1.357
     R08963  Androstan-3alpha,17beta-diol + NADP+ <=> Dihydrotestosterone + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.50
   R10423  3alpha-Hydroxysteroid <=> 3-Oxosteroid
    R08963  Androstan-3alpha,17beta-diol <=> Dihydrotestosterone
  1.1.1.357
   R10423  3alpha-Hydroxysteroid <=> 3-Oxosteroid
    R08963  Androstan-3alpha,17beta-diol <=> Dihydrotestosterone
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
K00089  3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]
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