KEGG   REACTION: R09403
Entry
R09403                      Reaction                               
Name
L-isoleucine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
L-Isoleucine + 2 Oxygen + 2 [Reduced NADPH---hemoprotein reductase] <=> (E)-2-Methylbutanal oxime + 2 [Oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O
Equation
C00407 + 2 C00007 + 2 C03024 <=> C19491 + 2 C03161 + C00011 + 3 C00001
Comment
three-step reaction (see R10027+R10028+R10029)
The enzyme can also accept L-valine as substrate, with a lower activity.(1.14.14.38)
3step reaction (similar to R00730+R04460+R07190)
Reaction class
RC00001  C00005_C00006
RC02339  C00407_C19491
Enzyme
1.14.14.39
Pathway
rn00966  Glucosinolate biosynthesis
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.39
     R09403  L-Isoleucine + 2 Oxygen + 2 [Reduced NADPH---hemoprotein reductase] <=> (E)-2-Methylbutanal oxime + 2 [Oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O
Orthology
K14984  isoleucine N-monooxygenase [EC:1.14.14.39]
Other DBs
RHEA: 28605
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