KEGG   REACTION: R09543
Entry
R09543                      Reaction                               
Name
S-adenosyl-L-methionine:malonyl-[acyl-carrier protein] O-methyltransferase
Definition
S-Adenosyl-L-methionine + Malonyl-[acyl-carrier protein] <=> S-Adenosyl-L-homocysteine + Malonyl-[acp] methyl ester
Equation
Comment
Malonyl-[acp] is a far better acceptor of methyl groups from S-adenosyl-L-methionine than was malonyl-CoA.
Reaction class
RC00003  C00019_C00021
RC00460  C01209_C19673
Enzyme
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00572  Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.197
     R09543  S-Adenosyl-L-methionine + Malonyl-[acyl-carrier protein] <=> S-Adenosyl-L-homocysteine + Malonyl-[acp] methyl ester
Orthology
K02169  malonyl-CoA O-methyltransferase [EC:2.1.1.197]
Reference
1  [PMID:22965231]
  Authors
Lin S, Cronan JE
  Title
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
  Journal
J Biol Chem 287:37010-20 (2012)
DOI:10.1074/jbc.M112.410290
Other DBs
RHEA: 17108
LinkDB

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