Entry |
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Definition |
5 ATP + 3 L-4-Hydroxyphenylglycine + L-Arginine + L-Serine + H2O <=> 5 AMP + 5 Diphosphate + Nocardicin G + L-4-Hydroxyphenylglycyl-L-arginine
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Equation |
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Comment |
nocardicin nonribosomal peptide synthetase
(1) 3 L-pHPG + L-Arg + L-Ser + 5 ATP <=> Pro-nocardicin G + 5 AMP + 5 Diphosphate
(2) Pro-nocardicin G + H2O <=> Nocardicin G + L-pHPG-L-Arg
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Reaction class |
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Pathway |
rn01110 | Biosynthesis of secondary metabolites |
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Module |
M00736 | Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A |
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Orthology |
K19102 | nocardicin nonribosomal peptide synthetase NocA |
K19103 | nocardicin nonribosomal peptide synthetase NocB |
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Reference |
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Authors |
Gaudelli NM, Long DH, Townsend CA |
Title |
beta-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis. |
Journal |
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Reference |
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Authors |
Gaudelli NM, Townsend CA |
Title |
Epimerization and substrate gating by a TE domain in beta-lactam antibiotic biosynthesis. |
Journal |
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LinkDB |
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