KEGG   REACTION: R11151
Entry
R11151                      Reaction                               
Name
rifampicin:NADH:oxygen oxidoreductase (2-hydroxy-2,27-secorifampicin-forming; ring-cleaving)
Definition
Rifampicin + NADH + Oxygen + H+ <=> 2-Hydroxy-2,27-secorifampicin + NAD+ + H2O
Equation
C06688 + C00004 + C00007 + C00080 <=> C22649 + C00003 + C00001
Comment
NADPH (see R11152)
Reaction class
RC00001  C00003_C00004
RC03585  C06688_C22649
Enzyme
1.14.13.211
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.211
     R11151  Rifampicin + NADH + Oxygen + H+ <=> 2-Hydroxy-2,27-secorifampicin + NAD+ + H2O
Orthology
K21267  rifampicin monooxygenase [EC:1.14.13.211]
Reference
1  [PMID:29578336]
  Authors
Liu LK, Dai Y, Abdelwahab H, Sobrado P, Tanner JJ.
  Title
Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge.
  Journal
Biochemistry 57:2065-2068 (2018)
DOI:10.1021/acs.biochem.8b00190
Other DBs
RHEA: 48991
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