KEGG   REACTION: R11283
Entry
R11283                      Reaction                               
Name
2'''-N-acetyl-6'''-deamino-6'''-hydroxyparomomycin-II hydrolase (acetate-forming)
Definition
2'''-N-Acetyl-6'''-deamino-6'''-hydroxyparomomycin II + H2O <=> 6'''-Deamino-6'''-hydroxyparomomycin II + Acetate
Equation
C21261 + C00001 <=> C21262 + C00033
Comment
deduced reaction
Reaction class
RC00166  C21261_C21262
RC00300  C00033_C21261
Enzyme
3.5.1.-
Pathway
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-
     R11283  2'''-N-Acetyl-6'''-deamino-6'''-hydroxyparomomycin II + H2O <=> 6'''-Deamino-6'''-hydroxyparomomycin II + Acetate
Orthology
K20583  deacetylase [EC:3.5.1.-]
Reference
1  [PMID:21689223]
  Authors
Clausnitzer D, Piepersberg W, Wehmeier UF
  Title
The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin.
  Journal
J Appl Microbiol 111:642-51 (2011)
DOI:10.1111/j.1365-2672.2011.05082.x
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