KEGG   REACTION: R11445
Entry
R11445                      Reaction                               
Name
malonyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, methylating, 2-methylbutanoate-forming)
Definition
2 Malonyl-CoA + Acyl-carrier protein + 2 NADPH + 2 H+ + S-Adenosyl-L-methionine <=> (S)-2-Methylbutanoyl-[acp] + 2 CoA + 2 CO2 + 2 NADP+ + S-Adenosyl-L-homocysteine + H2O
Equation
2 C00083 + C00229 + 2 C00005 + 2 C00080 + C00019 <=> C21129 + 2 C00010 + 2 C00011 + 2 C00006 + C00021 + C00001
Comment
Acy-carrier protein is acp domain of the enzyme itself [KO:K20984].
Reaction class
RC00039  C00229_C21129
Enzyme
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00893  Lovastatin biosynthesis, malonyl-CoA => lovastatin acid
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.244
     R11445  2 Malonyl-CoA + Acyl-carrier protein + 2 NADPH + 2 H+ + S-Adenosyl-L-methionine <=> (S)-2-Methylbutanoyl-[acp] + 2 CoA + 2 CO2 + 2 NADP+ + S-Adenosyl-L-homocysteine + H2O
Orthology
K20984  2-methylbutanoate polyketide synthase [EC:2.3.1.244]
Other DBs
RHEA: 42855
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