KEGG   REACTION: R11516
Entry
R11516                      Reaction                               
Name
malonyl-CoA:malonamoyl-[acyl-carrier protein] malonyltransferase
Definition
Malonamoyl-[acyl-carrier protein] + 8 Malonyl-CoA <=> 18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + 8 CO2 + 8 CoA
Equation
C21430 + 8 C00083 <=> C12441 + 8 C00011 + 8 C00010
Comment
There are two proposed pathways for biosynthesis of the malonamate starter unit (see R06641).
Enzyme
2.3.1.260
Pathway
rn00253  Tetracycline biosynthesis
rn01056  Biosynthesis of type II polyketide backbone
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.260
     R11516  Malonamoyl-[acyl-carrier protein] + 8 Malonyl-CoA <=> 18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + 8 CO2 + 8 CoA
Orthology
K05551  minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05552  minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05553  minimal PKS acyl carrier protein
Other DBs
RHEA: 38370
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