KEGG   REACTION: R11688
Entry
R11688                      Reaction                               
Name
(S)-1-hydroxy-N-methylcanadine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (13-hydroxylating)
Definition
(S)-1-Hydroxy-cis-N-methylcanadine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (13S,14R)-1,13-Dihydroxy-cis-N-methylcanadine + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C21586 + C03024 + C00007 <=> C21587 + C03161 + C00001
Reaction class
RC01552  C21586_C21587
Enzyme
1.14.14.163
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.163
     R11688  (S)-1-Hydroxy-cis-N-methylcanadine + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (13S,14R)-1,13-Dihydroxy-cis-N-methylcanadine + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K22094  (S)-1-hydroxy-N-methylcanadine 13-hydroxylase [EC:1.14.14.163]
Reference
1  [PMID:25485687]
  Authors
Dang TT, Chen X, Facchini PJ
  Title
Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.
  Journal
Nat Chem Biol 11:104-6 (2015)
DOI:10.1038/nchembio.1717
LinkDB

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