KEGG   REACTION: R12262
Entry
R12262                      Reaction                               
Name
S-adenosyl-L-methionine:narcotoline 4'-O-methyltransferase
Definition
Narcotoline + S-Adenosyl-L-methionine <=> alpha-Narcotine + S-Adenosyl-L-homocysteine
Equation
Reaction class
RC00392  C09592_C09593
Enzyme
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.352
     R12262  Narcotoline + S-Adenosyl-L-methionine <=> alpha-Narcotine + S-Adenosyl-L-homocysteine
Orthology
K23157  3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase subunit OMT2 [EC:2.1.1.352]
K23158  3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase subunit OMT3
Reference
1  [PMID:29723437]
  Authors
Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ
  Title
Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
  Journal
Plant J 95:252-267 (2018)
DOI:10.1111/tpj.13947
Reference
2  [PMID:27378283]
  Authors
Li Y, Smolke CD
  Title
Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
  Journal
Nat Commun 7:12137 (2016)
DOI:10.1038/ncomms12137
LinkDB

DBGET integrated database retrieval system