KEGG   REACTION: R12323
Entry
R12323                      Reaction                               
Name
lanosterol,reduced ferredoxin:oxygen oxidoreductase (14-methyl cleaving)
Definition
Lanosterol + 6 Reduced ferredoxin + 6 H+ + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 6 Oxidized ferredoxin + 4 H2O
Equation
C01724 + 6 C00138 + 6 C00080 + 3 C00007 <=> C11455 + C00058 + 6 C00139 + 4 C00001
Reaction class
RC01442  C01724_C11455
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.36
     R12323  Lanosterol + 6 Reduced ferredoxin + 6 H+ + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 6 Oxidized ferredoxin + 4 H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.15.36
   R12317  14alpha-Methylsteroid <=> Delta14-Steroid
    R12323  Lanosterol <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
Orthology
K05917  sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]
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