KEGG REACTION: R12328

REACTION: R12328

Entry

R12328                      Reaction

Name

acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, NADH)

Definition

Acetyl-CoA + n Malonyl-CoA + n NADPH + n NADH + 2n H+ <=> Long-chain acyl-CoA + n CoA + n CO2 + n NADP+ + n NAD+ + n H2O

Equation

C00024 + n C00083 + n C00005 + n C00004 + 2n C00080 <=> C02843 + n C00010 + n C00011 + n C00006 + n C00003 + n C00001

Comment

Type I fatty acid synthase, bacteria type
multi-step reaction (see map00061)

Enzyme

2.3.1.-

Pathway

rn00061

Fatty acid biosynthesis

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.-
     R12328  Acetyl-CoA + n Malonyl-CoA + n NADPH + n NADH + 2n H+ <=> Long-chain acyl-CoA + n CoA + n CO2 + n NADP+ + n NAD+ + n H2O

Orthology

K11533

fatty acid synthase, bacteria type [EC:2.3.1.-]

Reference

1 [PMID:21204864]

Authors

Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H.

Title

Fatty acid biosynthesis in actinomycetes.

Journal

FEMS Microbiol Rev 35:475-97 (2011)
DOI:10.1111/j.1574-6976.2010.00259.x

Reference

2 [PMID:15353567]

Authors

Schweizer E, Hofmann J.

Title

Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.

Journal

Microbiol Mol Biol Rev 68:501-17, table of contents (2004)
DOI:10.1128/MMBR.68.3.501-517.2004

LinkDB

DBGET integrated database retrieval system