KEGG   REACTION: R12403
Entry
R12403                      Reaction                               
Name
4alpha-methylzymosterol,ferrocytochrome-b5:oxygen oxidoreductase (hydroxylating)
Definition
4alpha-Methylzymosterol + 6 Ferrocytochrome b5 + 3 Oxygen + 6 H+ <=> 4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 Ferricytochrome b5 + 4 H2O
Equation
C05103 + 6 C00999 + 3 C00007 + 6 C00080 <=> C22112 + 6 C00996 + 4 C00001
Comment
three-step reaction
Reaction class
RC03537  C05103_C22112
Enzyme
1.14.18.9
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, FPP => cholesterol
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.9
     R12403  4alpha-Methylzymosterol + 6 Ferrocytochrome b5 + 3 Oxygen + 6 H+ <=> 4alpha-Carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 Ferricytochrome b5 + 4 H2O
Orthology
K07750  methylsterol monooxygenase [EC:1.14.18.9]
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