KEGG   REACTION: R12424
Entry
R12424                      Reaction                               
Name
[glycine cleavage system H]-N6-octanoyl-L-lysine:[Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster sulfurtransferase
Definition
[Glycine cleavage system H]-N6-octanoyl-L-lysine + [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-Adenosyl-L-methionine + 2 Reduced [2Fe-2S] ferredoxin + 8 H+ <=> Dihydrolipoylprotein + [Fe-S] cluster scaffold protein + 2 Hydrogen sulfide + 4 Fe2+ + 2 L-Methionine + 2 5'-Deoxyadenosine + 2 Oxidized [2Fe-2S] ferredoxin
Equation
C22159 + C22154 + 2 C00019 + 2 C22150 + 8 C00080 <=> C02972 + C22155 + 2 C00283 + 4 C14818 + 2 C00073 + 2 C05198 + 2 C22151
Enzyme
Pathway
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00881  Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H
M00882  Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H
M00883  Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.8  Transferring sulfur-containing groups
   2.8.1  Sulfurtransferases
    2.8.1.8
     R12424  [Glycine cleavage system H]-N6-octanoyl-L-lysine + [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster + 2 S-Adenosyl-L-methionine + 2 Reduced [2Fe-2S] ferredoxin + 8 H+ <=> Dihydrolipoylprotein + [Fe-S] cluster scaffold protein + 2 Hydrogen sulfide + 4 Fe2+ + 2 L-Methionine + 2 5'-Deoxyadenosine + 2 Oxidized [2Fe-2S] ferredoxin
Orthology
K03644  lipoyl synthase [EC:2.8.1.8]
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