KEGG   REACTION: R12858
Entry
R12858                      Reaction                               
Definition
Xanthotoxin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5-Hydroxyxanthotoxin + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C01864 + C03024 + C00007 <=> C02951 + C03161 + C00001
Enzyme
1.14.14.165
Pathway
rn00999  Biosynthesis of various plant secondary metabolites
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.165
     R12858  Xanthotoxin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 5-Hydroxyxanthotoxin + [Oxidized NADPH---hemoprotein reductase] + H2O
Orthology
K23137  indole-3-carbonyl nitrile 4-hydroxylase [EC:1.14.14.165]
Reference
1  [PMID:18291319]
  Authors
Kruse T, Ho K, Yoo HD, Johnson T, Hippely M, Park JH, Flavell R, Bobzin S
  Title
In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures.
  Journal
Chem Biol 15:149-56 (2008)
DOI:10.1016/j.chembiol.2008.01.008
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