| Entry |
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| Name |
poly[(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl] amidohydrolase
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| Definition |
Poly[(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl] + H2O <=> Heparosan D-glucuronate + Acetate
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| Equation |
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| Reaction class |
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| Enzyme |
3.5.1.-
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| Brite |
Enzymatic reactions [BR:br08201]
3. Hydrolase reactions
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.1 In linear amides
3.5.1.-
R13046 Poly[(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl] + H2O <=> Heparosan D-glucuronate + Acetate
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| Orthology |
| K02576 | heparan sulfate N-deacetylase/N-sulfotransferase NDST1 [EC:3.5.1.- 2.8.2.8] |
| K02577 | heparan sulfate N-deacetylase/N-sulfotransferase NDST2 [EC:3.5.1.- 2.8.2.8] |
| K02578 | heparan sulfate N-deacetylase/N-sulfotransferase NDST3 [EC:3.5.1.- 2.8.2.8] |
| K02579 | heparan sulfate N-deacetylase/N-sulfotransferase NDST4 [EC:3.5.1.- 2.8.2.8] |
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| Reference |
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| Authors |
Humphries DE, Sullivan BM, Aleixo MD, Stow JL. |
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| Title |
Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network. |
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| Journal |
Biochem J 325 ( Pt 2):351-7 (1997) |
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| Reference |
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| Authors |
Missaghian P, Dierker T, Khosrowabadi E, Axling F, Eriksson I, Ghanem A, Kusche-Gullberg M, Kellokumpu S, Kjellen L. |
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| Title |
A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation. |
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| Journal |
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| LinkDB |
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