KEGG   REACTION: R13082
Entry
R13082                      Reaction                               
Name
3-hydroxyphloretin acylhydrolase (phloroglucinol-forming)
Definition
3-Hydroxyphloretin + H2O <=> 3,4-Dihydroxyphenylpropanoate + Phloroglucinol
Equation
Reaction class
RC00800  C10447_C22567
RC00801  C02183_C22567
Enzyme
Pathway
rn00946  Degradation of flavonoids
rn01100  Metabolic pathways
Module
M00967  Flavone degradation, luteolin/apigenin => DHCA/phloretate
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.4
     R13082  3-Hydroxyphloretin + H2O <=> 3,4-Dihydroxyphenylpropanoate + Phloroglucinol
Orthology
K22906  phloretin hydrolase [EC:3.7.1.4]
Reference
1  [PMID:14532034]
  Authors
Schoefer L, Mohan R, Schwiertz A, Braune A, Blaut M.
  Title
Anaerobic degradation of flavonoids by Clostridium orbiscindens.
  Journal
Appl Environ Microbiol 69:5849-54 (2003)
DOI:10.1128/AEM.69.10.5849-5854.2003
Reference
2  [PMID:33542233]
  Authors
Yang G, Hong S, Yang P, Sun Y, Wang Y, Zhang P, Jiang W, Gu Y.
  Title
Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
  Journal
Nat Commun 12:790 (2021)
DOI:10.1038/s41467-021-20974-2
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