KEGG   REACTION: R13215
Entry
R13215                      Reaction                               
Name
5alpha-pregnan-17alpha-ol-3,20-dione:NADP+ Delta4-oxidoreductase
Definition
5alpha-Pregnan-17alpha-ol-3,20-dione + NADP+ <=> 17alpha-Hydroxyprogesterone + NADPH + H+
Equation
C22831 + C00006 <=> C01176 + C00005 + C00080
Reaction class
RC00145  C01176_C22831
Enzyme
1.3.1.22
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.22
     R13215  5alpha-Pregnan-17alpha-ol-3,20-dione + NADP+ <=> 17alpha-Hydroxyprogesterone + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.1.22
   R13214  3-Oxo-5alpha-steroid <=> 3-Oxo-Delta4-steroid
    R13215  5alpha-Pregnan-17alpha-ol-3,20-dione <=> 17alpha-Hydroxyprogesterone
Orthology
K12343  3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]
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