KEGG   REACTION: R13216
Entry
R13216                      Reaction                               
Name
5alpha-pregnane-3alpha,17alpha-diol-20-one:NAD+ oxidoreductase
Definition
5alpha-Pregnan-17alpha-ol-3,20-dione + NADH + H+ <=> 5alpha-Pregnane-3alpha,17alpha-diol-20-one + NAD+
Equation
C22831 + C00004 + C00080 <=> C22832 + C00003
Reaction class
RC00144  C22831_C22832
Enzyme
1.1.1.239       1.1.1.357
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.239
     R13216  5alpha-Pregnan-17alpha-ol-3,20-dione + NADH + H+ <=> 5alpha-Pregnane-3alpha,17alpha-diol-20-one + NAD+
    1.1.1.357
     R13216  5alpha-Pregnan-17alpha-ol-3,20-dione + NADH + H+ <=> 5alpha-Pregnane-3alpha,17alpha-diol-20-one + NAD+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.357
   R10422  3alpha-Hydroxysteroid <=> 3-Oxosteroid
    R13216  5alpha-Pregnane-3alpha,17alpha-diol-20-one <=> 5alpha-Pregnan-17alpha-ol-3,20-dione
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
K00089  3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
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