KEGG   REACTION: R13221
Entry
R13221                      Reaction                               
Name
dihydrotestosterone:NAD+ 17-oxidoreductase
Definition
5alpha-Androstane-3,17-dione + NADH + H+ <=> Dihydrotestosterone + NAD+
Equation
C00674 + C00004 + C00080 <=> C03917 + C00003
Reaction class
RC00127  C00674_C03917
Enzyme
1.1.1.51
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51
     R13221  5alpha-Androstane-3,17-dione + NADH + H+ <=> Dihydrotestosterone + NAD+
Orthology
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Reference
1  [PMID:24189185]
  Authors
Rizner TL, Penning TM
  Title
Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.
  Journal
Steroids 79:49-63 (2014)
DOI:10.1016/j.steroids.2013.10.012
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