KEGG REACTION: R13255

REACTION: R13255

Entry

R13255                      Reaction

Name

acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, NADH, very-long-chain acyl-CoA forming)

Definition

Acetyl-CoA + n Malonyl-CoA + n NADPH + n NADH + 2n H+ <=> Very-long-chain acyl-CoA + n CoA + n CO2 + n NADP+ + n NAD+ + n H2O

Equation

C00024 + n C00083 + n C00005 + n C00004 + 2n C00080 <=> C20876 + n C00010 + n C00011 + n C00006 + n C00003 + n C00001

Comment

Type I fatty acid synthase, bacteria type
multi-step reaction

Enzyme

2.3.1.-

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.-
     R13255  Acetyl-CoA + n Malonyl-CoA + n NADPH + n NADH + 2n H+ <=> Very-long-chain acyl-CoA + n CoA + n CO2 + n NADP+ + n NAD+ + n H2O

Orthology

K11533

fatty acid synthase, bacteria type [EC:2.3.1.-]

Reference

1 [PMID:26104214]

Authors

PaweLczyk J, Kremer L

Title

The Molecular Genetics of Mycolic Acid Biosynthesis.

Journal

Microbiol Spectr 2:MGM2-0003-2013 (2014)
DOI:10.1128/microbiolspec.MGM2-0003-2013

Reference

2 [PMID:21204864]

Authors

Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H.

Title

Fatty acid biosynthesis in actinomycetes.

Journal

FEMS Microbiol Rev 35:475-97 (2011)
DOI:10.1111/j.1574-6976.2010.00259.x

Reference

3 [PMID:24374164]

Authors

Marrakchi H, Laneelle MA, Daffe M.

Title

Mycolic acids: structures, biosynthesis, and beyond.

Journal

Chem Biol 21:67-85 (2014)
DOI:10.1016/j.chembiol.2013.11.011

Reference

4 [PMID:27268593]

Authors

Quemard A.

Title

New Insights into the Mycolate-Containing Compound Biosynthesis and Transport in Mycobacteria.

Journal

Trends Microbiol 24:725-738 (2016)
DOI:10.1016/j.tim.2016.04.009

LinkDB

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