KEGG   REACTION: R13257
Entry
R13257                      Reaction                               
Name
long-chain-acyl-CoA:malonyl-[acyl-carrier protein] C-acyltransferase
Definition
Long-chain acyl-CoA + Malonyl-[acyl-carrier protein] <=> Long-chain 3-oxoacyl-[acyl-carrier protein] + CoA + CO2
Equation
Comment
general reaction
Reaction class
RC00004  C00010_C02843
Enzyme
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.301
     R13257  Long-chain acyl-CoA + Malonyl-[acyl-carrier protein] <=> Long-chain 3-oxoacyl-[acyl-carrier protein] + CoA + CO2
Orthology
K11608  mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.301]
Reference
1  [PMID:10840036]
  Authors
Choi KH, Kremer L, Besra GS, Rock CO
  Title
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis.
  Journal
J Biol Chem 275:28201-7 (2000)
DOI:10.1074/jbc.M003241200
Reference
2  [PMID:16040614]
  Authors
Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS.
  Title
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
  Journal
J Biol Chem 280:32539-47 (2005)
DOI:10.1074/jbc.M413216200
Reference
3  [PMID:18096200]
  Authors
Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA.
  Title
Probing reactivity and substrate specificity of both subunits of the dimeric  Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA  substrates.
  Journal
Bioorg Chem 36:85-90 (2008)
Reference
4  [PMID:21204864]
  Authors
Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H.
  Title
Fatty acid biosynthesis in actinomycetes.
  Journal
FEMS Microbiol Rev 35:475-97 (2011)
DOI:10.1111/j.1574-6976.2010.00259.x
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