KEGG   REACTION: R13268
Entry
R13268                      Reaction                               
Name
ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)
Definition
Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein] + H2O
Equation
Comment
general reaction
Enzyme
4.2.1.-
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     R13268  Ultra-long-chain mono-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Ultra-long-chain mono-unsaturated trans-2-enoyl-[acyl-carrier protein] + H2O
Orthology
K27071  meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadA [EC:4.2.1.-]
K27072  meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadB [EC:4.2.1.-]
Reference
1  [PMID:17804795]
  Authors
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A
  Title
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104
Reference
2  [PMID:15653820]
  Authors
Takayama K, Wang C, Besra GS.
  Title
Pathway to synthesis and processing of mycolic acids in Mycobacterium  tuberculosis.
  Journal
Clin Microbiol Rev 18:81-101 (2005)
Reference
3  [PMID:22216317]
  Authors
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D.
  Title
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define  the specificity of the mycolic acid elongation complexes.
  Journal
PLoS One 6:e29564 (2011)
DOI:10.1371/journal.pone.0029564
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