KEGG   REACTION: R13272
Entry
R13272                      Reaction                               
Name
ultra-long-chain-di-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein]-forming)
Definition
Ultra-long-chain di-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein] + H2O
Equation
C22871 <=> C22872 + C00001
Comment
general reaction
Enzyme
4.2.1.-
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     R13272  Ultra-long-chain di-unsaturated (3R)-3-hydroxyacyl-[acyl-carrier protein] <=> Ultra-long-chain di-unsaturated trans-2-enoyl-[acyl-carrier protein] + H2O
Orthology
K27072  meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadB [EC:4.2.1.-]
K27073  meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadC [EC:4.2.1.-]
K27074  meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadD [EC:4.2.1.-]
Reference
1  [PMID:17804795]
  Authors
Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffe M, Backbro K, Quemard A
  Title
The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.
  Journal
Proc Natl Acad Sci U S A 104:14628-33 (2007)
DOI:10.1073/pnas.0704132104
Reference
2  [PMID:15653820]
  Authors
Takayama K, Wang C, Besra GS.
  Title
Pathway to synthesis and processing of mycolic acids in Mycobacterium  tuberculosis.
  Journal
Clin Microbiol Rev 18:81-101 (2005)
Reference
3  [PMID:22216317]
  Authors
Cantaloube S, Veyron-Churlet R, Haddache N, Daffe M, Zerbib D.
  Title
The Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define  the specificity of the mycolic acid elongation complexes.
  Journal
PLoS One 6:e29564 (2011)
DOI:10.1371/journal.pone.0029564
Reference
4  [PMID:26538472]
  Authors
Slama N, Jamet S, Frigui W, Pawlik A, Bottai D, Laval F, Constant P, Lemassu A, Cam K, Daffe M, Brosch R, Eynard N, Quemard A.
  Title
The changes in mycolic acid structures caused by hadC mutation have a dramatic  effect on the virulence of Mycobacterium tuberculosis.
  Journal
Mol Microbiol 99:794-807 (2016)
DOI:10.1111/mmi.13266
Reference
5  [PMID:29662082]
  Authors
Lefebvre C, Boulon R, Ducoux M, Gavalda S, Laval F, Jamet S, Eynard N, Lemassu A, Cam K, Bousquet MP, Bardou F, Burlet-Schiltz O, Daffe M, Quemard A
  Title
HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness.
  Journal
Sci Rep 8:6034 (2018)
DOI:10.1038/s41598-018-24380-5
Reference
6  [PMID:32034201]
  Authors
Lefebvre C, Frigui W, Slama N, Lauzeral-Vizcaino F, Constant P, Lemassu A, Parish T, Eynard N, Daffe M, Brosch R, Quemard A
  Title
Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis.
  Journal
Sci Rep 10:2112 (2020)
DOI:10.1038/s41598-020-58967-8
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