Actinomadura sp. WMMB 499: F7P10_24260
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Entry
F7P10_24260 CDS
T06213
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
actw
Actinomadura sp. WMMB 499
Pathway
actw00860
Porphyrin metabolism
actw01100
Metabolic pathways
actw01110
Biosynthesis of secondary metabolites
actw01120
Microbial metabolism in diverse environments
actw01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
actw00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
F7P10_24260
Enzymes [BR:
actw01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
F7P10_24260
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
F7P10_24260
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
QFG27268
UniProt:
A0A5J6UKE8
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Position
5421351..5422871
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AA seq
506 aa
AA seq
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MGPGDPELLTLRAAAELENADTVVVSRAHCPDTVLAHCRPDAEIVDTAEGDPVKLAARAA
KAGRRVVRLFRGDPGLGCGLAAEGGALAKAGVPFEVVPGVSAVTGVPGYAGIPLTDPDHR
EVRVVDASHGGVDWTAYADPAATLVVLGAEHAVAETCKGLVAAGRSDRTPAAMTSLGTTT
EQETVVSTLHKLASEAKGMEAPAMIIVGDVVKHRDRLSWFETKPLFGWRVLVPRTKEQAA
SLSDQLRGYGAVPDEVPTISVEPPRTPQQMDRAVKGLVTGRYEWVVFTSTNAVKAIREKF
TAYGLDARAFAGLKVAAVGEQTAAALVEFGVVPDLTPEGQQSGEGLAEVWPPYDEDLDPI
NRVLLPRADIATDTLIARLTDLGWECEDVTAYRTVRAAPPPAPIREAIKGGGFDAVLFTS
SSTVKNLIGIAGKPHNVTVIAVIGPQTAKTAEEYGLRVDVMAPRPSVSALAEALAEYGAK
RRATQVENGDPLRKPSQMRRGARRRK
NT seq
1521 nt
NT seq
+upstream
nt +downstream
nt
atgggtccgggcgacccggaactgctgaccctgcgcgccgccgccgaactcgagaacgcc
gacaccgtcgtcgtcagccgggcgcactgccccgacacggtgctcgcgcactgccgtccc
gacgccgagatcgtcgacaccgccgagggcgaccccgtcaagctcgccgcgcgcgccgcg
aaggccggacgccgcgtcgtccggctgttccggggcgacccgggcctcggctgcgggctg
gccgccgagggcggcgcgctcgccaaggccggggtgccgttcgaggtcgtcccgggcgtg
tcggcggtgacgggcgtgccgggctacgcggggatcccgctgaccgaccccgaccaccgc
gaggtccgcgtcgtcgacgcgtcccacggcggcgtcgactggacggcctacgccgacccg
gccgcgaccctggtcgtcctcggcgccgagcacgcggtcgccgagacctgcaagggcctg
gtcgccgccggccgctccgaccgcaccccggcggcgatgacgagcctcggcacgaccacc
gagcaggagaccgtcgtgtcgaccctgcacaagctcgcgtccgaggccaagggcatggag
gcccccgcgatgatcatcgtgggggacgtcgtcaagcaccgcgaccggctgtcgtggttc
gagacgaagccgctgttcggctggcgcgtgctggtaccgcgcacgaaggagcaggccgcg
tccctgtcggaccagctccgcgggtacggcgccgtccccgacgaggtcccgacgatctcc
gtcgagccgccgcgcaccccccagcagatggaccgtgccgtcaaggggctcgtgaccgga
cggtacgagtgggtggtcttcacctcgaccaacgcggtcaaggcgatccgggagaagttc
accgcctacgggctggacgcccgcgcgttcgcgggcctgaaggtcgcggccgtcggcgag
cagaccgccgccgcgctcgtcgagttcggcgtcgtccccgacctgacccccgaggggcag
cagtccggcgagggcctggccgaggtgtggccgccctacgacgaggacctcgaccccatc
aaccgggtgctgctgccgcgcgccgacatcgccaccgacaccctgatcgcccggctgacc
gacctcggctgggagtgcgaggacgtcaccgcgtaccggacggtccgggcggcgccgccg
cccgcgccgatccgcgaggcgatcaagggcggcgggttcgacgcggtgctgttcacctcg
tcgtcgacggtgaagaacctcatcgggatcgccgggaagccgcacaacgtcaccgtcatc
gccgtgatcggcccgcagacggccaagacggccgaggagtacgggctgcgcgtcgacgtc
atggcgcccagaccgtccgtgtccgccctcgcggaggcgctcgccgagtacggtgccaag
cggcgggcgacgcaggtcgagaacggcgacccgctgcgcaagccgtcccagatgcgccgg
ggcgcccgccgccgcaagtag
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