| Entry |
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| Symbol |
tylG3
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| Name |
(KEGG) tylactone synthase modules 4 & 5
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| KO |
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| Taxonomy |
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| Lineage |
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces |
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| Organism |
Streptomyces fradiae
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| Module |
| 1906_M00773 | Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin |
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| AA seq |
3729 aa
MSTENSTNVPASEDKLRAYLRRAMADLHESRERLRATEARAQEPIAVVGMGCRFPGGVGS
PEALWRLVVEGVDAVSPFPGDRGWDVEGLYDPEPGVAGKSYVREGGFLHDAAEFDAEFFG
ISPREAVAMDPQQRLLLETSWEAIERAGIDPHSLHGSRTGVYAGVMYHDYGTGQTSATDT
SGYSGTGTSGSVVSGRVAYTLGLEGPAVTVDTACSSSLVALHLAVQALRGGECDMALAGG
VTVMAGPGMFVEFSRQRGLAADGRCKAFADGADGTAWAEGAGVVLVERLSDARRLGHPVL
AVVCGSAVNQDGASNGLTAPSGPSQERVIRQALANARLTVADVDVVEAHGTGTRLGDPIE
AQALLGTYGRDRDGGRPVWLGSLKSNIGHAQAAAGVAGVIKMVLAMRYGWLPRTLHVDEP
SRHVDWSAGGVWLLTEAREWPGVDRPRRAAVSAFGVSGTNAHLILEAPDTAEAESATTPV
RSEVSESAAVFDARSGVVPVVVSGRSRVVVREAAGRLAEVVEAGGVGLADVAVTMAGRSR
FGYRAVVLARGEAELAGRLRALAGGDPDAGVVTGAVVDPETGSGGGGVVLVFPGQGTQWV
GMGAGLLGSSEVFAASMRECARALSVHVGWDLLEVVSGGAGLERVDVVQPVTWAVMVSLA
RYWQAMGVDVAAVVGHSQGEIAAATVAGALSLEDAAAVVALRAGLIGRYLAGRGAMAAVP
LPAGEVEAGLAKWPGVEVAAVNGPASTVVSGDRRAVAGYVAVCQAEGVQARLIPVDYASH
SRHVEDLKGELERVLSGIRPRSPRVPVCSTVAGEQPGEPVFDAGYWFRNLRNRVEFSAVV
GGLLEEGHRRFIEVSAHPVLVHAIEQTAEAADRSVHATGTLRRQDDSPHRLLTSTAEAWA
HGATLTWDPALPPGHLTTLPTYPFNHHHYWLDTTPTTPATTTQSPTDAQNPADALPYKVS
WKRLRDQDSLTARLDGRWLLVVPEASADPSVAEGVARELTARGATVESLTVEPGADRSRL
RGLLVDATERDEAGPLRGIVSLLALAGDHAGADGARPVVPAGLAASLALIQAAGDAGTEA
GLWAVTRGAVAAVPGDVPAPSQALLWGFGRVAGIELPHCWGGLLDLPTGPGDSGFRQLAA
TLAGRPAEDQVALRASGAYGRRLVRASAAGGADGWRPRGTVLVVGDTAEVAGPLVRWLLG
NGARRVTLSGLSGPLPEELADVAARVTVAPCDPADRPALRTLLAEQAPTAVLVAPPAVPP
TPLAEMTAEALAIALSAKTGLVDRLDSLLDEPDPLLEDGELDAFVVFSSVAGVWGGAGQG
GYAAGTAYLDALAECRRAGGLPVTSVAWTPWLGTPAADSLGEQMSRAGITPLDPAASLDA
LARAVGRRAGCVTVADIDWERFASAYTATRPTPMFDEVPEVRRIQAAWAEAEADAARSGA
GGDSQLLRSLRGRPEEAQLAELLRLVRTHAAAVLGLGSPGAVEARRSFKDLGFNSVTAVE
LRNRLKEATGLRLEVSLVFDHPDPASLARHLLDLALGQEPEETPRAFALEPAPNGEPIAI
VSMACRMPGGVSTPEELWRLLRDGKDAIGPFPANRGWDLENLYDPDPDADGRTYVREGGF
LHEAPDFDPSFFGISPREALAMDPQQRLLLETSWEALERAGIDPARLRGSRTGVFVGTNG
QHYMPLLQNGGDSFDGYLGTGNSASVMSGRLSYVFGLEGPAVTVDTACSASLVALHLAVQ
AMRRGECDMALVGGATVMSTPEMLVEFSRQRVISANGRSRAFAAGADGVALGEGVGVLLV
ERLSDAERNGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALADAGLRPEDIDAV
EAHGTGTELGDPIEAEALLATYGRTRTADRPLWLGSLKSNIGHTQAAAGVAGVIKMVLAL
GNETLPRTLHVDEPTPRVDWSSGAVSLLTEPVDWPAGPSAPRRAAVSSFGISGTNAHTIL
EQAPVPAESRPGTEPADGTGAWENVTVPLLLSGHTEAALREQSTRLLNDLLEHPDEHPAD
VGYTLITGRAHFGHRAAVIGESREELLDALKALAEGREHHTVVRGDGTAHPDRRVVFVFP
GQGSQWPSMARDLLDRAPAFRETAKACDAALSVHLDWSVLDVLQEKPDAPPLSRVDVVQP
VLFTMMLSLAACWRDLGVHPAAVVGHSQGEIAAACVAGALSLEDAARIVALRSRAWLTLA
GKGGMAAVSLPEARLRERIERFGQRLSVAAVNSPGTAAVAGDVDALRELLAELTAEGIRA
KPIPGVDTAGHSAQVDGLKEHLFEVLAPVSPRSSDIPFYSTVTGAPLDTERLDAGYWYRN
MREPVEFEKAVRALIADGYDLFLECNPHPMLAMSLDETLTDSGGHGTVMHTLRRQKGSAK
DFGMALCLAYVNGLEIDGEALFGPDSRRVNPPTYPFQRERYWYHPTSGRRGDITAAGVAE
AEHPLLGAGVELPETGGTVYTARFGPDSRPWLADHALLGTVLLPGTAILDLVLWAGERSG
CGRVGELALQAPLVLPDSGDVELRLLVGGPDEEKRRTVTVHARPAAAGAEAPWTRHAEAV
VLPATGEEPTPAPRPVPEPAGTTDPAAFYAEFAERGYDYGPAFQGFTAGARHGEDVVAEV
ALPSGLVADARHHRLHPALLDAALQAMILGTFFADDGRARMPFAVRGVRLHTAGADRLRV
LISPAGDETVRLLCTDLATGAPVLEIDELVVRPVSGEQLAAGAPGRNGGELYRVDWTVLP
EPAEVPAPRWALLGEDHAGLADVLGGTGGGCERYDTLTGLLEATTRSAGGILPDIVALSL
PTAPEPGPQAVREVLSQALDAAQAWLAAGAETASARLVFVTGGAVATTADETVRDIAAAA
VWGLVRSAQSEEPDRMVLLDLDGERPTARTLAAALASGEPQLAVRGSTVAAPRLAPAGPG
PEDLVPPAGTTAWRLTPGGGTLEELSLAPAPDAEEPLAPGQVRIAVRAAGVNFRDALIAL
GMYPGKGTMGAEGAGVVVETAPDVTGLSAGDRVLGMWNGGFGPLVVADHRMVAPIPHGWS
YAEAASVPAVLLTSYYALTRLARARTGQTVLVHAAAGGVGMATLQLARHLGLEVYATAST
GKWDALQKHGIPDDRIADSRTLDFAERFLSRTGGRGVDIVLNSLAGEFVDASLRLLPRGG
HFLELGKADVRDPRRIAAAHPGTDYRAFDLVQAGPDTVGEMLGELLELFAAGALRPLPLT
AYGIRDARTALRTLSQARHTGKLVLTVPAGFDTHRTVLLTGGTGTLGQTLARHLVNRHGV
RHLLLAGRTGAAAEGVAELIGELGELGAEVRVAACDAADRQRLTELLAGIPVEHPLGAVV
HAAGTLDDGTIPSLTGENIDNVLRPKADAVLNLHELTRDADLSAFVLYSSSSALLGSPGQ
GAYAAANAFLDGFARYRKGLGLPALSLAWGLWGSNSRMAGHLDQSGMQRRLNRSGIMALT
DAEGLALFDAAQDGGDALLVPMRLNRTALRASGRITPFLSGLAGGGPAAGERRPEVAAVS
GTLAERLTGLTAQEGHALVLAEIRAHAAAVLGHGSDDSIPEDRAFKDLGFDSLTAVEMRN
RLSAATGLRLPATLVFDHPTPGELAGHLSAELSADDAPGSASPLTELDRFEALFTALAPG
TTKDTPGGAGALMIDEAERQEIAGRLAALAGLWNRLHGTTTAPEDGDTVADALEAADDHE
IFAFLDERF |
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| Comment |
Unpublished sequence data: DeHoff BS, Sutton KL, Rosteck PR Jr (1996).
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