| Entry |
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| Symbol |
pikC
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| Name |
(KEGG) pikromycin synthase (EC:1.14.15.33)
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| KO |
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| Taxonomy |
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| Lineage |
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces |
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| Organism |
Streptomyces venezuelae
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| Module |
| 54571_M00776 | Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin |
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| AA seq |
416 aa
MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDR
ARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLR
PRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVF
PDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHIL
LVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVE
PVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLA
RLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWRRGREAGRRTG |
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| Reference |
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| Authors |
Xue Y, Zhao L, Liu HW, Sherman DH |
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| Title |
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity. |
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| Journal |
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| Reference |
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| Authors |
Xue Y, Wilson D, Zhao L, Liu H, Sherman DH |
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| Title |
Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae. |
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| Journal |
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