Entry
Symbol
tylE
Name
(KEGG) demethylmacrocin O-methyltransferase (EC:2.1.1.102)
KO
Taxonomy
Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces fradiae
Taxonomy
Module
1906_M00773 Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
SSDB
Ortholog Paralog GFIT
Motif
Motif
Other DBs
LinkDB
All DBs
AA seq
395 aa AA seq DB search
MAVQKEATLVRQIIRAAGGHAADVRELVAEHGPEAVTAVLVDEIVSRAPHPVNDVPVLVE
LAVRSGDALVPRRLAVAQGAPVRRAAPDDDGFVAMRVEYELDELVRELFGPCRERAAGTR
GTTLFPYATSGTGHIDTYFLAAQQATATVLAGCTSAKPDLNELTSRYLTPKWGSLHWFTP
HYDRHFREYRNEEVRVLEIGIGGYQHPEWGGGSLRMWKHFFHRGLIYGLDIEDKSHAEEQ
RITTVVGDQNDPGCLTELAARYGPFDIVIDDGSHINEHVRTSFHALFPHVRPGGLYVIED
LWTAYWPGFGGDSDPGKSDLTSLGLVKSLVDSLQHQELPEDSGRSPGYADRHVVGLHVYH
NLAFIEKGVNSEGGIPGWIPRDFDALVAASSGGAA
Reference
Authors
Kreuzman AJ, Turner JR, Yeh WK
Title
Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.
Journal
J Biol Chem 263:15626-33 (1988)