KEGG   Addendum: AAF82408
Entry
AAF82408          CDS       T10000                                 
Symbol
oleAI
Name
(KEGG) 8,8a-deoxyoleandolide synthase 1
  KO
K16007  8,8a-deoxyoleandolide synthase 1
Taxonomy
TAX:1890
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces antibioticus
Module
1890_M00775  Oleandomycin biosynthesis, malonyl-CoA + methylmalonyl-CoA => 8,8a-deoxyoleandolide => oleandomycin
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 Ketoacyl-synt_C KR KAsynt_C_assoc PP-binding adh_short Epimerase Thiolase_N adh_short_C2 PKS_DE GDP_Man_Dehyd Polysacc_synt_2 ACP_syn_III RmlD_sub_bind NAD_binding_4
Other DBs
NCBI-ProteinID: AAF82408
GB: AF220951
UniProt: Q9KIV4
LinkDB
AA seq 4150 aa
MHVPGEENGHSIAIVGIACRLPGSATPQEFWRLLADSADALDEPPAGRFPTGSLSSPPAP
RGGFLDSIDTFDADFFNISPREAGVLDPQQRLALELGWEALEDAGIVPRHLRGTRTSVFM
GAMWDDYAHLAHARGEAALTRHSLTGTHRGMIANRLSYALGLQGPSLTVDTGQSSSLAAV
HMACESLARGESDLALVGGVNLVLDPAGTTGVERFGALSPDGRCYTFDSRANGYARGEGG
VVVVLKPTHRALADGDTVYCEILGSALNNDGATEGLTVPSARAQADVLRQAWERARVAPT
DVQYVELHGTGTPAGDPVEAEGLGTALGTARPAEAPLLVGSVKTNIGHLEGAAGIAGLLK
TVLSIKNRHLPASLNFTSPNPRIDLDALRLRVHTAYGPWPSPDRPLVAGVSSFGMGGTNC
HVVLSELRNAGGDGAGKGPYTGTEDRLGATEAEKRPDPATGNGPDPAQDTHRYPPLILSA
RSDAALRAQAERLRHHLEHSPGQRLRDTAYSLATRRQVFERHAVVTGHDREDLLNGLRDL
ENGLPAPQVLLGRTPTPEPGGLAFLFSGQGSQQPGMGKRLHQVFPGFRDALDEVCAELDT
HLGRLLGPEAGPPLRDVMFAERGTAHSALLSETHYTQAALFALETALFRLLVQWGLKPDH
LAGHSVGEIAAAHAAGILDLSDAAELVATRGALMRSLPGGGVMLSVQAPESEVAPLLLGR
EAHVGLAAVNGPDAVVVSGERGHVAAIEQILRDRGRKSRYLRVSHAFHSPLMEPVLEEFA
EAVAGLTFRAPTTPLVSNLTGAPVDDRTMATPAYWVRHVREAVRFGDGIRALGKLGTGSF
LEVGPDGVLTAMARACVTAAPEPGHRGEQGADADAHTALLLPALRRGRDEARSLTEAVAR
LHLHGVPMDWTSVLGGDVSRVPLPTYAFQRESHWLPSGEAHPRPADDTESGTGRTEASPP
RPHDVLHLVRSHAAAVLGHSRAERIDPDRAFRDLGFDSLTALELRDRLDTALGLRLPSSV
LFDHPSPGALARFLQGDDTRRPEPGKTNGTRATEPGPDPDDEPIAIVGMACRFPGGVTSP
EDLWRLLAAGEDAVSGFPTDRGWNVTDSATRRGGFLYDAGEFDAAFFGISPREALVMDPQ
QRLLLETSWEALERAGVSPGSLRGSDTAVYIGATAQDYGPRLHESDDDSGGYVLTGNTAS
VASGRIAYSLGLEGPAVTVDTACSSSLVALHLAVQALRRGECSLALAGGATVMPSPGMFV
EFSRQGGLSEDGRCKAFAATADGTGWAEGVGVLLVERLSDARRLGHRVLAVVRGSAVNQD
GASNGLTAPNGPSQQRVIRAALADAGLVPADVDVVEAHGTGTRLGDPIEAQALLATYGQG
RAGGRPVVLGSVKSNIGHTQAAAGVAGVMKMVLALGRGVVPKTLHVDEPSAHVDWSAGEV
ELAVEAVPWSRGGRVRRAGVSSFGISGTNAHVIVEEAPAEPEPEPERGPGSVVGVVPWVV
SGRDAGALREQAARLAAHVSGVSAVDVGWSLVATRSVFEHRAVMVGSELDAMAESLAGFA
AGGVVPGVVSGVAPAEGRRVVFVFPGQGSQWVGMAAGLLDACPVFAEAVAECAAVLDPLT
GWSLVEVLRGGGEAVLGRVDVVQPALWAVMVSLARTWRYYGVEPAAVVGHSQGEIAAACV
AGGLSLADGARVVVLRSRAIARIAGGGGMVSVSLPAGRVRTMLEEFDGRVSVAAVNGPSS
TVVSGDVQALDELLAGCEREGVRARRVPVDYASHSAQMDQLRDDLLEALATIVPTSANVP
FFSTVTADWLDTTALDAGYWFTNLRETVRFQEAVEGLVAQGMGAFVECSPHPVLVPGITE
TLDTFDADAVALSSLRRDEGGLDRFLTSLAEAFVQGVPVDWSRAFEGASPRTVDLPTYPF
QRQRYWLLDKAAQRERERLEDWRYHVEWRPVTTRPSARLSGVWAVAIPARLARDSLLVGA
IDALERGGARAVPVVVDERDHDRQALVEALRNGLGDDDLAGVLSLLALDEAPHGDHPDVP
VGMAASLALVQAMADAAAEVPVWFATRGAVAALPGESPERPRQALLWGLGRVVALEQPQI
WGGLVDLPQHLDEDAGRRLVDVVGGLADEDQLAVRASSVLARRLVRTPGHRMSSQAGGRE
WSPSGTVLVTGGTGALGAHVARWLAGKGAEHLVLISRRGADAAGAAALRDSLTDMGVRVT
LAACDAADRHALETLLDSLRTDPAQLTAVIHAAGALDDGMTTVLTPEQMNNALRAKVTAT
VNLHELTRDLDLSAFVLFSSISATLGIPGQANYAPGNSFLDAFAEWRRAQGLVATSIAWG
PWSGGTGMAHEGSVGERLQRHGVLAMEPAAAIAALDHTLASDETAVAVADIDWSRFFLAY
TALRARPLIGEIPEARRMLESGSGPGDLEPDRAEPELAVRLAGLTAVEQERLLVQLVREQ
AAVVLGHSGAEAVAPDRAFKDLGFDSLTSVELRNRLNTATGLRLPVTAVFDYARPAALAG
HLRSRLIDDDGDHGALPGVEKHAIDEPIAIVGMACRFPGGIASPEDLWDVLTAGEDVVSG
LPQNRGWDLGRLYDPDPDRAGTSYMREGAFLHEAGEFDAAFFGISPREALAMDPQQRLLL
ETSWEALERAGITPSKLAGSPTGVFFGMSNQDYAAQAGDVPSELEGYLLTGSISSVASGR
VAYTFGLEGPAVTVDTACSSSLVALHLAVQGLRRGECSLALVGGVTVMSSPVTLTTFSRQ
RGLSVDGRCKAFAASADGFGAAEGVGVLLVERLSDARRLGHRVLAVVRGSAVNQDGASNG
LAAPNGPSQQRVIRAALADAGLAPADVDVVEAHGTGTRLGDPIEAQALLATYGQGRTSGR
PVWLGSVKSNIGHTQAAAGVAGVMKMVLALGRGVVPKTLHVDEPSPHVDWSAGEVELAVE
AVPWSRGGRVRRAGVSSFGISGTNAHVIVEEAPAEPSVEEGPGSVVGVVPWVVSGRDAGA
LRAQAARLAAHVSSTGAGVVDVGWSLVATRSVFEHRAVMVGTDLDSMAGSLAGFAAGGVV
PGVVSGVAPAEGRRVVFVFPGQGSQWVGMAAGLLDACPVFAEAVAECAAVLDRLTGWSLV
EVLRGGEAVLGRVDVVQPALWAVMVSLARTWRYYGVEPAAVVGHSQGEIAAACVAGGLSL
ADGARVVVLRSRAIARIAGGGGMVSVGLSAERVRTMLDTYGGRVSVAAVNGPSSTVVSGD
AQALDELLAGCEREGVRARRVPVDYASHSAQMDQLRDELLEALADVTPQDSSVPFFSTVT
ADWLDTTALDAGYWFTNLRETVRFQEAVEGLVAQGMGAFVECSPHPVLVPGITETLDTFD
ADAVALSSLRRDEGGLDRFLTSLAEAFVQGVPVDWTHAFEGGRPRFVDLPTYAFQRQRYW
LHEEPLQEPVDEAWDAEFWSVVERGDATAVSDLLSTDAEALHTVLPALSSWRRRRVEHRR
LQDWRYRVEWKPFPAALDEVLGGGWLFVVPRGLADDGVVARVVAAVTARGGEVSVVELDP
TRPDRRAYAEAVAGRGVSGVVSFLSWDDRRHSEHSVVPAGLAASLVLAQALVDLGRVGEG
PRLWLVTRGAVVAGPSDAGVVIDPVQAQVWGFGRVLGLEHPELWGGLVDLPVGVDEEVCR
RFVGVVASAGFEDQVAVRGSGVWVRRLVRAVVDGGGGGWRPRGTVLVTGGLGGLGAHTAR
WLVGGGADHVVLVSRRGGSAPGAGDLVRELEGLGGARVSVRACDVADRVALRALLSDLGE
PVTAVFHAAGVPQSTPLAEISVQEAADVMAAKVAGAVNLGELVDPCGLEAFVLFSSNAGV
WGSGGQAVYAAANAFLDALAVRRRGVGLPATSVAWGMWAGEGMASVGGAARELSRRGVRA
MDPERAVAVMADAVGRGEAFVAVADVDWERFVTGFASARPRPLISDLPEVRAVVEGQVQG
RGQGLGLVGEEESSGWLKRLSGLSRVRQEEELVELVRAQAAVVLGHGSAQDVPAERAFKE
LGFDSLTAVELRNGLAAATGIRLPATMAFDHPTATAIARFLQSELVGSDDPLTLMRSAID
QLETGLALLESDEEARSEITKRLNILLPRFGSGGSSRGREAGQDAGEHQDVEDATIDELF
EVLDNELGNS
Reference
PMID:10908114
  Authors
Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R
  Title
Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.
  Journal
J Antibiot (Tokyo) 53:502-8 (2000)
DOI:10.7164/antibiotics.53.502

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