| Entry |
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| Symbol |
megAII
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| Name |
(KEGG) megalomicin 6-deoxyerythronolide B synthase 2
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| KO |
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| Taxonomy |
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| Lineage |
Bacteria; Actinomycetota; Actinomycetes; Micromonosporales; Micromonosporaceae; Micromonospora |
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| Organism |
Micromonospora megalomicea
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| AA seq |
3562 aa
MTDNDKVAEYLRRATLDLRAARKRLRELQSDPIAVVGMACRLPGGVHLPQHLWDLLRQGH
ETVSTFPTGRGWDLAGLFHPDPDHPGTSYVDRGGFLDDVAGFDAEFFGISPREATAMDPQ
QRLLLETSWELVESAGIDPHSLRGTPTGVFLGVARLGYGENGTEAGDAEGYSVTGVAPAV
ASGRISYALGLEGPSISVDTACSSSLVALHLAVESLRLGESSLAVVGGAAVMATPGVFVD
FSRQRALAADGRSKAFGAAADGFGFSEGVSLVLLERLSEAESNGHEVLAVIRGSALNQDG
ASNGLAAPNGTAQRKVIRQALRNCGLTPADVDAVEAHGTGTTLGDPIEANALLDTYGRDR
DPDHPLWLGSVKSNIGHTQAAAGVTGLLKMVLALRHEELPATLHVDEPTPHVDWSSGAVR
LATRGRPWRRGDRPRRAGVSAFGISGTNAHVIVEEAPERTTERTVGGDVGPVPLVVSARS
AAALRAQAAQVAELVEGSDVGLAEVGRSLAVTRARHEHRAAVVASTRAEAVRGLREVAAV
EPRGEDTVTGVAETSGRTVVFLFPGQGSQWVGMGAELLDSAPAFADTIRACDEAMAPLQD
WSVSDVLRQEPGAPGLDRVDVVQPVLFAVMVSLARLWQSYGVTPAAVVGHSQGEIAAAHV
AGALSLADAARLVVGRSRLLRSLSGGGGMSAVALGEAEVRRRLRSWEDRISVAAVNGPRS
VVVAGEPEALREWGREREAEGVRVREIDVDYASHSPQIDRVRDELLTVTGEIEPRSAEIT
FYSTVDVRAVDGTDLDAGYWYRNLRETVRFADAMTRLADSGYDAFVEVSPHPVVVSAVAE
AVEEAGVEDAVVVGTLSRGDGGPGAFLRSAATAHCAGVDVDWTPALPGAATIPLPTYPFQ
RKPYWLRSSAPAPASHDLAYRVSWTPITPPGDGVLDGDWLVVHPGGSTGWVDGLAAAITA
GGGRVVAHPVDSVTSRTGLAEALARRDGTFRGVLSWVATDERHVEAGAVALLTLAQALGD
AGIDAPLWCLTQEAVRTPVDGDLARPAQAALHGFAQVARLELARRFGGVLDLPATVDAAG
TRLVAAVLAGGGEDVVAVRGDRLYGRRLVRATLPPPGGGFTPHGTVLVTGAAGPVGGRLA
RWLAERGATRLVLPGAHPGEELLTAIRAAGATAVVCEPEAEALRTAIGGELPTALVHAET
LTNFAGVADADPEDFAATVAAKTALPTVLAEVLGDHRLEREVYCSSVAGVWGGVGMAAYA
AGSAYLDALVEHRRARGHASASVAWTPWALPGAVDDGRLRERGLRSLDVADALGTWERLL
RAGAVSVAVADVDWSVFTEGFAAIRPTPLFDELLDRRGDPDGAPVDRPGEPAGEWGRRIA
ALSPQEQRETLLTLVGETVAEVLGHETGTEINTRRAFSELGLDSLGSMALRQRLAARTGL
RMPASLVFDHPTVTALARYLRRLVVGDSDPTPVRVFGPTDEAEPVAVVGIGCRFPGGIAT
PEDLWRVVSEGTSITTGFPTDRGWDLRRLYHPDPDHPGTSYVDRGGFLDGAPDFDPGFFG
ITPREALAMDPQQRLTLEIAWEAVERAGIDPETLLGSDTGVFVGMNGQSYLQLLTGEGDR
LNGYQGLGNSASVLSGRVAYTFGWEGPALTVDTACSSSLVAIHLAMQSLRRGECSLALAG
GVTVMADPYTFVDFSAQRGLAADGRCKAFSAQADGFALAEGVAALVLEPLSKARRNGHQV
LAVLRGSAVNQDGASNGLAAPNGPSQERVIRQALTASGLRPADVDMVEAHGTGTELGDPI
EAGALIAAYGRDRDRPLWLGSVKTNIGHTQAAAGAAGVIKAVLAMRHGVLPRSLHADELS
PHIDWADGKVEVLREARQWPPGERPRRAGVSSFGVSGTNAHVIVEEAPAEPDPEPVPAAP
GGPLPFVLHGRSVQTVRSQARTLAEHLRTTGHRDLADTARTLATGRARFDVRAAVLGTDR
EGVCAALDALAQDRPSPDVVAPAVFAARTPVLVFPGQGSQWVGMARDLLDSSEVFAESMG
RCAEALSPYTDWDLLDVVRGVGDPDPYDRVDVLQPVLFAVMVSLARLWQSYGVTPGAVVG
HSQGEIAAAHVAGALSLADAARVVALRSRVLRELDDQGGMVSVGTSRAELDSVLRRWDGR
VAVAAVNGPGTLVVAGPTAELDEFLAVAEAREMRPRRIAVRYASHSPEVARVEQRLAAEL
GTVTAVGGTVPLYSTATGDLLDTTAMDAGYWYRNLRQPVLFEHAVRSLLERGFETFIEVS
PHPVLLMAVEETAEDAERPVTGVPTLRRDHDGPSEFLRNLLGAHVHGVDVDLRPAVAHGR
LVDLPTYPFDRQRLWPKPHRRADTSSLGVRDSTHPLLHAAVDVPGHGGAVFTGRLSPDEQ
QWLTQHVVGGRNLVPGSVLVDLALTAGADVGVPVLEELVLQQPLVLTAAGALLRLSVGAA
DEDGRRPVEIHAAEDVSDPAEARWSAYATGTLAVGVAGGGRDGTQWPPPGATALTLTDHY
DTLAELGYEYGPAFQALRAAWQHGDVVYAEVSLDAVEEGYAFDPVLLDAVAQTFGLTSRA
PGKLPFAWRGVTLHATGATAVRVVATPAGPDAVALRVTDPTGQLVATVDALVVRDAGADR
DQPRGRDGDLHRLEWVRLATPDPTPAAVVHVAADGLDDLLRAGGPAPQAVVVRYRPDGDD
PTAEARHGVLWAATLVRRWLDDDRWPATTLVVATSAGVEVSPGDDVPRPGAAAVWGVLRC
AQAESPDRFVLVDGDPETPPAVPDNPQLAVRDGAVFVPRLTPLAGPVPAVADRAYRLVPG
NGGSIEAVAFAPVPDADRPLAPEEVRVAVRATGVNFRDVLLALGMYPEPAEMGTEASGVV
TEVGSGVRRFTPGQAVTGLFQGAFGPVAVADHRLLTPVPDGWRAVDAAAVPIAFTTAHYA
LHDLAGLQAGQSVLVHAAAGGVGMAAVALARRAGAEVFATASPAKHPTLRALGLDDDHIA
SSRESGFGERFAARTGGRGVDVVLNSLTGDLLDESARLLADGGVFVEMGKTDLRPAEQFR
GRYVPFDLAEAGPDRLGEILEEVVGLLAAGALDRLPVSVWELSAAPAALTHMSRGRHVGK
LVLTQPAPVHPDGTVLVTGGTGTLGRLVARHLVTGHGVPHLLVASRRGPAAPGAAELRAD
VEGLGATIEIVACDTADREALAALLDSIPADRPLTGVVHTAGVLADGLVTSIDGTATDQV
LRAKVDAAWHLHDLTRDADLSFFVLFSSAASVLAGPGQGVYAAANGVLNALAGQRRALGL
PAKALGWGLWAQASEMTSGLGDRIARTGVAALPTERALALFDAALRSGGEVLFPLSVDRS
ALRRAEYVPEVLRGAVRSTPRAANRAETPGRGLLDRLVGAPETDQVAALAELVRSHAAAV
AGYDSADQLPERKAFKDLGFDSLAAVELRNRLGVTTGVRLPSTLVFDHPTPLAVAEHLRS
ELFADSAPDVGVGARLDDLERALDALPDAQGHADVGARLEALLRRWQSRRPPETEPVTIS
DDASDDELFSMLDRRLGGGGDV |
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| Reference |
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| Authors |
Volchegursky Y, Hu Z, Katz L, McDaniel R |
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| Title |
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea. |
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| Journal |
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