KEGG   Addendum: ACN39730
Entry
ACN39730          CDS       T10000                                 
Symbol
sibG
Name
(KEGG) 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase (EC:1.14.13.223)
  KO
K21280  3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase [EC:1.14.13.223]
Taxonomy
TAX:457432
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales; Streptosporangiaceae; Streptosporangium
Organism
Streptosporangium sibiricum
SSDB
Motif
Pfam: FAD_binding_3 Lycopene_cycl Pyr_redox_2 SE FAD_oxidored
Other DBs
NCBI-ProteinID: ACN39730
GB: FJ768674
UniProt: C0LTM1
LinkDB
AA seq 351 aa
MRILVNGGGPAGMAFAMFAARSGRGDEITVRDWTGPGDTYGFGVILPPAAVEVFRDAEPD
LADELNSHITAWDRLSVHRHGRTASIPAPRLGAMDRRTLLKVLRRRCAERGVRFEHGAVD
PALGDHDLVVAADGARSVTRRHRAAAFGTTTREIGPAYIWLGADRALEHLRFLVAETPDG
PAVAHAYPYSPDRSTFLVEADGAPPPAVLAEWFAGPLGGARLLENRSRWSRFQEIHNRTW
SAGNVVLIGDAAHTAHYSIGSGTRLALDDARALADALCAQPRLADALKGYEDARRPIVEH
TQRIGRLSATWFTRLPDVPMERLLDDLATRGGQISWRDLATEGSGAVPVRG
Reference
  Authors
Li W, Khullar A, Chou S, Sacramo A, Gerratana B
  Title
Biosynthesis of sibiromycin, a potent antitumor antibiotic.
  Journal
Appl Environ Microbiol 75:2869-78 (2009)
DOI:10.1128/AEM.02326-08
Reference
  Authors
Giessen TW, Kraas FI, Marahiel MA
  Title
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.
  Journal
Biochemistry 50:5680-92 (2011)
DOI:10.1021/bi2006114

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