KEGG   Addendum: BAC57028
Entry
BAC57028          CDS       T10000                                 
Symbol
mycAI
Name
(KEGG) protomycinolide IV synthase 1
  KO
K24528  protomycinolide IV synthase 1
Taxonomy
TAX:28040
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Micromonosporales; Micromonosporaceae; Micromonospora
Organism
Micromonospora griseorubida
Module
28040_M00934  Mycinamicin biosynthesis, malonyl-CoA + methylmalonyl-CoA => protomycinolide IV => mycinamicin II
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 Ketoacyl-synt_C KR KAsynt_C_assoc PP-binding PKS_DH_N Thiolase_N PS-DH adh_short Epimerase Polysacc_synt_2 GDP_Man_Dehyd Creatininase NmrA NAD_binding_4 3Beta_HSD Se-cys_synth_N
Other DBs
NCBI-ProteinID: BAC57028
GB: AB089954
UniProt: Q83WF0
LinkDB
AA seq 4307 aa
MVVPSVTAAPESVALVGMSCRLPGASGVEEFWDLLTEGRDAVARQPDGSWRAALAETGTF
DAGFFGMSPRQAAAADPQQRLVLELGWEALEHAGVVPATLAGSRTGVFVGVTADDYATSL
WRTGTTPDGYTVPGLNRSMIANRLSYLLELRGPSFVVDSAQSSSLVAVHLACESLLRGES
DAAIVAGVSLISTPESTAAMASLGALSPDGRCYTFDARANGYVRGEGGAAVVLKRLSDAL
VDGDRVHAVILGGAVNNDGGGPGLLAPDRAAQEEVLRRAYDRSGVGPAQVTYVELHGTGT
PVGDPVEAAALGAVFGADRRADDPLHVGSVKSNIGHLEGAAGITGLLKAVLCVREGVLPP
TLNHQTPNPGIPLAQLRLRVQTTVQRWPDRADEGRRIAAVSSFGMGGTNAHLVLAQAPER
AVRPAVSPTTELPAVPWVLSARSEAALRGQAERLREHLDRHPDLRPLDVGFSLATSRDVF
PHRSVRFADGEPVAAGSGRLAEGRVAWVFPGQGAQWTGMAAASLTESPVFAARLTECAAA
VTPFVDWSLLDVLRAVPGSPRLDRDDVVQPACFAVMVSLAELWRSWGVVPEAVVGHSQGE
IAAAVVAGAISLEDGARIVALRSQLLTRELHGLGGMVSVGLPVAETERLLTRWSGRLHLA
VVNGPNATVVAGDGDALDELVTECERRQARVRRVAVEYASHSPHVERIRDELMTALRPVT
PQPSAVAFYSTADVGITDGERLDAGYWYRNLRQPVRFADTLRQMSTDGYTSFVELSAHPM
LVTALEEILAQETTAALCVTGSLRRDEGGLGRMLASAAEGWAHGLPVDWRKVFAGTGAER
VELPTYAFQRQRYWAPDAERTAVPPAAVDAPVRPAASPPEQATPAQATTQQTYDLLRTVL
ETVATVQGLPSAETVDPDLTFKEQGLESYAAVEFRNRLRARVGLSLPATLVYDFPTPTAV
AGFLGDQLHPRESQLVTVTPALVDDEPIAIVGMGCRFPGGVSSPEDLWDVVASGVDAVSP
FPVDRGWDLESLFDGDPDRAGTTYCREGGFLDDAAGFDAGFFGVSPREAVAMDPQQRLLL
EGVVEGVGAGGFSSAGVRGSRTGVYAGVMNQEYGPRLYESAEEHRGYLLTGTAASVVSGR
VSYVLGLEGPAVTVDTACSSSLVALHLAVQALRSGECDVALAGGVTVMATPGIFVEFSRQ
GGLAVDGRCKAYSDSADGTGWSEGVGVVVVQRLSDAVAAGRRVLAVVRGSAVNQDGASNG
LTAPSGSSQQRVIRAALASARLSVGDVDVVEGHGTGTRLDPIEAQALLATYGRRGGGRSL
LLGSVKSNIGHAQAAAGVAGVVKMVLAMERGVVPASLHVRCAVFACQDWSSGAVEVVGEA
CAWPETGRPRRAAVSSFGVSGTNAHVILEQAPPVVPDASSSAGAPVSAVSDADSSSVSVP
WVLSARSEWGLRASAGRLEAALSGPLSGSGSGSGVVSGVDVGWSLGGRSVFGWRGVSLSG
VGRLGVLAGGGVGSGVVVGSGRVASGGVVFVFPGQGAQWVGMARGLLGESGVFSEAFDEV
GGVVQGLVDWPVRGTACREVGRGDLGRVDVVQPLSFVVMVALARLSRSSGVVPPGWVGHS
QGEIAAAVVSGALSVEEGARVVVGRSRVIGARLAGGGAMVWVGASVGVVEGLLGGLGGGL
EVAVVNGPGQVVVAGDGGWGGGVVGAGVGGWGVRARLLPVGYGSHCGLVDVVRDELLGVL
GEVRGGSSVIPFYSSVDVGVVDGGVLDGGYWFRNLRLRVRFGEVVRRLVGDGFSSFVEVS
AHPVLVGAIEDVLGEVGGGVGFVCGGFVAVGVDGGLGRMVVSAAEGWVRGLPVQWRRVPV
LAGGRQVGLPTYPFQHDRYWLAPAPRTAVAAGATAADGAAAGVGWRYRVGWKALPVPTPG
RLHGRWLVVHGHATGGVDQLSGVVADILTRHGATTEHLTIDPAEPGVLAERLGALAAAGE
PVRGVVSLLDLDGTLLLVQAMGRAGLDARIRAVTTGAVAVSSDEVPSSEGAALWAFGRVA
ALELPDRWAGLIDLPVQADARALERLAGALTSEEENQLAVRASGLYTRRIIRTAGRARKE
WRPRGTVLVTGGTGALGARVARWLADHGAEHLVLVSRRGAQATGAAELVAGLERTGVRVT
VAACDVADRDGAGRPAGGAPTAGGLPHRWRARRPDGGPAHSRGSGCGVPAERLAATHLHD
LTAHRDLDAFVLFSSIVGSWGNAGQAAYAAANAALDALAEQRRSAGLPATSIAWGLWAGA
GMADGAGEQTFTRRGVRAMDPDDGIAALRQALDSGDTCVTVADVDWPSMVRTHANPAAAR
LFEEIPEARQALADRAAEQSAERPSDLARRLTGLTAADRRRLLLDLIGAQAAVILRQDSG
WTIPPDSAFRASGFDSLTALELRNRLNAATGLTLPSTVVFDHPSPVALADFLLDAVLPRS
GGADGVVEVAAAPDEPIAVIGVGCRYPGGVATPEQLWDLLLTERDAIGPLPTDRGWNIDD
IFDPEPGRVGRTYCREGGFLHDAADFDAAFFGISPREALAMDPQQRLILETSWEALERAG
IDPRSLRGSRTGVYTGMTHQEYAARLHEMPEEYEGHLLTGTSGSVASGRVSYVLGLEGPA
VTVDTACSSSLVAIHLAVQALRAGECDLALAGGVTVMATRDCSWSSPASGASPRRPVQGV
LRQADGTGWSEGAGVITLARLSDAVRDGRHILALIRGPRSTRTVPATGSPRRTGRHSSAS
SRLALANAGLTPPEVDAVEAHGTGTRLGDPIEAGALLATYGQGRPVDQPVRLGTLKSNIG
HTQAAAGVAGMIKMVLALRHGVLPATLHATEPSPHIDWNAGAVSLLTERTDWPDNPRPRR
AAVSAFGISGTNAHIILEQAPEPTVPSERSERAAGPRLSVVPWPLSGRSEPALRAQAARL
RDFLDDGADPVDVGFSLATTRSRLDHRAVVLLDGETAPTEALHALVSGDAGRAVLSGTPR
DTALAFLFTGQGSQRLGMADGIRREFPPFAEALAEIAAEMDTRLDQPLLSVMFAEPGSAT
ATLIDRTEYAQPALFAVEVALFRLFESWGVRPDVLLGHSVGEIAAAHVAGVMDLEHACRL
VAARGRLMQRMPADGAMIAIRLPEERVREQLHDLGRHVSVAAVNGPESVVVSGAGHVVRS
LADQLTAEGHRVRRLNVSHAFHSPHVDEVLEEFRKAAAEVRYGRPLVPVVSNVTGRVATE
DELGSAEYWVRHLREPVRFHDGIRTLLDRGATTLVELGPDGVLCGLAAQCLDPDRDEVAL
VPALHRTSGEVRSLVAAAATVHVRGHDVDWNGFFAETGARRVDLPTYAFQRQRYWASVSP
PGSDQTAAVRFGLNAADHPLLGGALSVAGSEDLIFTGRLSLAAQPWIAGHRVGERAAARY
AFLEVASRAGRAVGGDRVRDLQIEAPLVVPDRGAVQVQVVLTGGDEPDGRQVRVFARPEG
STAPWTRHATGNGDAAGGSGRRPGVGALVAPEGAVPLDVGDLYRRFAAQHLEYDGVFTGV
RELWRRADEVFAEVRLPDGAEVEAAAFGVHPALLDAALQPWLAGDFVSRPADSVHLPFAW
QGMQVHTSGAAALRVRIRRAGESAVSMQAVAVDGAPVCSLDALVLRPTTVRSLRRTVGPA
LLPLHHLRWREREPGQAPGTPLTFLGPTGAERYVGEAVTVHQDLTALRAVGQRGAPPPRA
VLAAFGSPHRTAEAVRAVAAAALDLVQRWLADDRHQDSRLVLVTERAVAADDHEDVPDLA
GAAVWGLVRSAQSEHPGRFALIDHDGTEQSRALLPAAVALGCAQLALRQGTVRVPALAAL
PPTESGADTRLAPDGTVLVTGAAGALGALVVRHLVAEHGVRRLLLLSRHGREAAGMAELA
EDLAQRGVTVTVLACDVADRTGLAAALDAVPDEHPLTAVVHAAGVLDDAMVTGLTADRLD
EVLRPKVDAALHLHELTADRKLAAFVLFSAAAGLLGNPGQASYAAANTVLDALAHHRRAN
GLPATSLAWGVLGGPNGMAANLNAAHLRRLARYGIAPLDGDEARSLLDRALRTDRALLVP
LRLTRVDARQDPADVPEILRPLVVPVVADGGGRSPATGPNSLEAFRAQLAELDDGTRGEH
LLDLVRRQVAEVLGHDRADVVDPKRPFQDLGFDSLLAVELRNRLQAATGLPLPATLGFDH
PTPQTVVDHLAESLLSRPEGDPGEQALTGLDAVARALTKLGDEDIRRVVVRRRLAELLAT
VAGAEPDLANGGGTGAGVDDGHDDTALVERLSGASDEDLLAFIDEQI
Reference
PMID:12583909
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x

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