KEGG   Arvicanthis niloticus (African grass rat): 117694504
Entry
117694504         CDS       T08817                                 
Symbol
Araf
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
anu  Arvicanthis niloticus (African grass rat)
Pathway
anu01521  EGFR tyrosine kinase inhibitor resistance
anu01522  Endocrine resistance
anu04010  MAPK signaling pathway
anu04012  ErbB signaling pathway
anu04068  FoxO signaling pathway
anu04270  Vascular smooth muscle contraction
anu04650  Natural killer cell mediated cytotoxicity
anu04720  Long-term potentiation
anu04726  Serotonergic synapse
anu04730  Long-term depression
anu04810  Regulation of actin cytoskeleton
anu04910  Insulin signaling pathway
anu04914  Progesterone-mediated oocyte maturation
anu04928  Parathyroid hormone synthesis, secretion and action
anu05010  Alzheimer disease
anu05022  Pathways of neurodegeneration - multiple diseases
anu05034  Alcoholism
anu05160  Hepatitis C
anu05161  Hepatitis B
anu05200  Pathways in cancer
anu05205  Proteoglycans in cancer
anu05208  Chemical carcinogenesis - reactive oxygen species
anu05210  Colorectal cancer
anu05211  Renal cell carcinoma
anu05212  Pancreatic cancer
anu05213  Endometrial cancer
anu05214  Glioma
anu05215  Prostate cancer
anu05218  Melanoma
anu05219  Bladder cancer
anu05220  Chronic myeloid leukemia
anu05221  Acute myeloid leukemia
anu05223  Non-small cell lung cancer
anu05224  Breast cancer
anu05225  Hepatocellular carcinoma
anu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:anu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    117694504 (Araf)
   04012 ErbB signaling pathway
    117694504 (Araf)
   04068 FoxO signaling pathway
    117694504 (Araf)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    117694504 (Araf)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    117694504 (Araf)
  09152 Endocrine system
   04910 Insulin signaling pathway
    117694504 (Araf)
   04914 Progesterone-mediated oocyte maturation
    117694504 (Araf)
   04928 Parathyroid hormone synthesis, secretion and action
    117694504 (Araf)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    117694504 (Araf)
  09156 Nervous system
   04726 Serotonergic synapse
    117694504 (Araf)
   04720 Long-term potentiation
    117694504 (Araf)
   04730 Long-term depression
    117694504 (Araf)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117694504 (Araf)
   05205 Proteoglycans in cancer
    117694504 (Araf)
   05208 Chemical carcinogenesis - reactive oxygen species
    117694504 (Araf)
  09162 Cancer: specific types
   05210 Colorectal cancer
    117694504 (Araf)
   05212 Pancreatic cancer
    117694504 (Araf)
   05225 Hepatocellular carcinoma
    117694504 (Araf)
   05226 Gastric cancer
    117694504 (Araf)
   05214 Glioma
    117694504 (Araf)
   05221 Acute myeloid leukemia
    117694504 (Araf)
   05220 Chronic myeloid leukemia
    117694504 (Araf)
   05218 Melanoma
    117694504 (Araf)
   05211 Renal cell carcinoma
    117694504 (Araf)
   05219 Bladder cancer
    117694504 (Araf)
   05215 Prostate cancer
    117694504 (Araf)
   05213 Endometrial cancer
    117694504 (Araf)
   05224 Breast cancer
    117694504 (Araf)
   05223 Non-small cell lung cancer
    117694504 (Araf)
  09172 Infectious disease: viral
   05161 Hepatitis B
    117694504 (Araf)
   05160 Hepatitis C
    117694504 (Araf)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    117694504 (Araf)
   05022 Pathways of neurodegeneration - multiple diseases
    117694504 (Araf)
  09165 Substance dependence
   05034 Alcoholism
    117694504 (Araf)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117694504 (Araf)
   01522 Endocrine resistance
    117694504 (Araf)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:anu01001]
    117694504 (Araf)
Enzymes [BR:anu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     117694504 (Araf)
Protein kinases [BR:anu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   117694504 (Araf)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 117694504
NCBI-ProteinID: XP_034341336
EnsemblRapid: ENSANLG00005020774
LinkDB
Position
X:complement(606810..618380)
AA seq 605 aa
MEPPRNPPVSGAEPSRAVGTVKVYLPNKQRTVVTVREGMTVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEAPSNLSVNELL
TPQGPSSFPQHRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPVDSSLMQFTTQSFS
TDAAGRSGGDGAPRGSPSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGY
YWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKT
RHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLH
AKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQ
DPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKA
MRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSA
ARLVP
NT seq 1818 nt   +upstreamnt  +downstreamnt
atggaaccaccacgaaaccctcctgttagtggggctgagccatctcgggcagttggcact
gtcaaagtatacctgcctaacaagcaacgcacggtggtgactgtccgggaaggcatgact
gtctatgactctttggacaaggccctcaaggtgcggggcctcaatcaggactgctgtgtg
gtctacagactcatcaaaggaagaaagacagtcactgcctgggacacagccattgcacct
ttggatggtgaagagctcattgtggaggtcctggaagatgtgccgctgaccatgcacaat
tttgtccggaagacgttcttcagcctggccttctgtgacttctgccttaagtttctgttc
catggattccgctgccagacctgtggctacaagttccaccagcattgttcctccaaggtt
cccaccgtctgcgttgacatgagtaccaaccgccgacagttctaccacagcatccaggat
ttgtctggaggctccaggcagcaggaggctccctcaaatctctctgtgaatgagctgcta
accccccagggtcccagctcctttccccagcaccgtgaccaggagcacttctccttccct
gcccctgccaatcccccactgcagcgcatccgttccacatctactcctaacgtccacatg
gtcagcaccacagctcccgtggactccagcctcatgcagtttactactcagagcttcagc
accgatgctgctggcagaagtggtggtgacggagcccctcggggtagccctagcccagct
agtgtgtcttcagggaggaagtccccacattccaagttaccttcagaacagcgggagcgg
aagtccttggcagatgaaaagaaaaaagtgaagaacctggggtaccgggactcaggctat
tactgggaggtgccacccagtgaggtacagctgttgaagaggatcgggacaggctctttt
ggcactgtgtttcgggggcgttggcatggcgatgtagctgtgaaggtactcaaggtggcc
caacctaccgctgagcaggcccaggccttcaagaatgaaatgcaggtgctcaggaagaca
cgacatgtcaacattttgctgttcatgggtttcatgactcggccagggtttgccatcatc
acacagtggtgtgagggttccagcctctaccaccacctacatgtggctgacacgcgcttt
gacatggtccagctcattgacgtggcccggcagactgcccagggcatggactacctccac
gccaagaacatcattcaccgagacctaaagtccaacaatatcttcctacatgaggggctc
acagtcaagattggtgacttcggcctggccacggtgaagacacggtggagtggggcccag
cccttagagcagccctcggggtctgtgctatggatggcagctgaggtgatccgtatgcag
gacccgaacccctacagcttccagtcggatgtctatgcctatggtgttgtgctgtatgag
cttatgaccggctcactgccctacagccacattggcagccgtgaccagatcatctttatg
gtgggccgtggctatctgtctccggacctcagcaaaatcttcagtaattgccccaaagcc
atgaggcgcctgctgactgactgcctcaagttccagcgggaggagcggcccctatttccc
cagattctggccacgatcgagctactgcagcggtcactccccaagattgagcggagtgcc
tccgaaccatccttgcaccgcacccaggctgatgagttgcctgcctgccttctcagcgca
gcccgccttgtgccttag

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