Amycolatopsis keratiniphila: AORI_7963
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Entry
AORI_7963 CDS
T02678
Symbol
pdhA
Name
(GenBank) pyruvate dehydrogenase E1 component subunit alpha
KO
K00166
2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:
1.2.4.4
]
Organism
aoi
Amycolatopsis keratiniphila
Pathway
aoi00280
Valine, leucine and isoleucine degradation
aoi00640
Propanoate metabolism
aoi00785
Lipoic acid metabolism
aoi01100
Metabolic pathways
aoi01110
Biosynthesis of secondary metabolites
aoi01210
2-Oxocarboxylic acid metabolism
Module
aoi_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
aoi00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
AORI_7963 (pdhA)
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
AORI_7963 (pdhA)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
AORI_7963 (pdhA)
Enzymes [BR:
aoi01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
AORI_7963 (pdhA)
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Motif
Pfam:
E1_dh
TPP_enzyme_C
DXP_synthase_N
Motif
Other DBs
NCBI-ProteinID:
AGM10544
UniProt:
R4T4L6
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All DBs
Position
8773375..8774580
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AA seq
401 aa
AA seq
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MPSEHWTHPEPGDGPAAVAAQPSPEQVIAGLRATSEGGAELTQLLTPEGERVASPQFDRY
VDDIDAEALKGLYRDMVLVRRADREANAMQRQGQLGIWVPLLGQEAAQIGSGRALRKGDM
AFPSYREHGVAYTRGVDLKEVLGIFRCTDHSGWDYKAHGFHPYTIVIGNQVLNAAGYAMG
QKFEGKVGDDDSEATICYFGDGATSQGDVHEGFVWAAVYDAPLVFFCQNNQWAISEPTER
QSRLPLYQRARGYGFPGIRVDGNDVLACLAVSRWALEECRHGNGPVLIEAFTYRMDAHTT
TDDPTRYRLSDELEEWKLKDPIERVRAYLARGGGADQAFFDQVQADSDAFAAELRDYCFN
MPEPPPDRIFSNVYAESTPLLDKQREEFLSYMDGFVGAGEH
NT seq
1206 nt
NT seq
+upstream
nt +downstream
nt
atgccgtccgaacactggacgcacccggagcctggagatggtcccgccgccgtagcggcg
cagccttcccccgaacaggtgatcgccggtttgcgagcaacgagcgaaggtggcgctgag
ctgactcagctgctcacccccgaaggcgaacgggtcgcctcgccgcaattcgaccgctac
gtcgacgacatcgacgccgaggccctcaagggcctgtaccgcgacatggtgctggtccgc
cgcgcggaccgcgaggccaacgcgatgcagcgccagggccagctcggcatctgggtgccg
ctgctcgggcaggaggccgcgcagatcggctccggccgcgcgctgcggaagggggacatg
gcgttccccagctaccgcgagcacggtgtcgcgtacacccgaggcgtcgacctcaaagag
gtgctcggcatcttccgctgcaccgaccacagcggctgggactacaaggcccacggcttc
cacccgtacaccatcgtgatcggcaaccaggtgctcaacgccgccggttacgcgatgggc
cagaagttcgaaggcaaggtcggcgacgacgacagcgaagcgaccatctgttacttcggt
gacggggcgacttcgcagggcgacgtgcacgaaggcttcgtctgggccgccgtctacgac
gcgccgctcgtgttcttctgccagaacaaccagtgggcgatctcggagcccaccgagcgc
cagtcgcgcctgccgctgtaccagcgcgcccgcggctacggcttccccggcatccgcgtg
gacggcaacgacgtcctcgcctgcctcgcggtctcccgctgggctctggaggagtgccga
cacggcaacggcccggtgctgatcgaggcgttcacctatcggatggacgcgcacaccacc
accgacgaccccacccgctaccggctctccgacgagctggaggagtggaagctgaaggac
ccgatcgagcgcgtccgggcgtacctcgcccgcggtggcggcgccgaccaggcgttcttc
gaccaggtgcaggccgattcggacgcgttcgcggccgagctgcgcgattactgcttcaac
atgccggaaccgccaccggaccggatcttctccaacgtgtacgcggagtccacgccgctg
ctggacaagcagcgcgaagagttcctgtcctacatggacggtttcgtcggggcgggtgag
cactga
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