Bubalus bubalis (water buffalo): 102391863
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Entry
102391863 CDS
T05912
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub05012
Parkinson disease
bbub05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
102391863 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
102391863 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bbub01001
]
102391863 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
bbub04131
]
102391863 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
bbub04147
]
102391863 (LRRK2)
Enzymes [BR:
bbub01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
102391863 (LRRK2)
Protein kinases [BR:
bbub01001
]
Serine/threonine kinases: TKL group
LRRK family
102391863 (LRRK2)
Membrane trafficking [BR:
bbub04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
102391863 (LRRK2)
Exosome [BR:
bbub04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
102391863 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
LRR_8
LRR_4
Roc
COR
Ras
LRR_9
Arf
Ank_2
LRR_6
T2SSE
nSTAND3
G-alpha
Kdo
GTP_EFTU
AAA_22
AAA_16
ABC_tran
PduV-EutP
AAA_7
NACHT
MMR_HSR1
MobB
TrwB_AAD_bind
AAA_29
cobW
FtsK_SpoIIIE
TniB
AAA_23
Arm
Motif
Other DBs
NCBI-GeneID:
102391863
NCBI-ProteinID:
XP_025139777
EnsemblRapid:
ENSBBUG00015021987
LinkDB
All DBs
Position
4:79597222..79809383
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEESLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQDKN
VHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPHDIGHDWEVLGVHQLIL
KMLTVHNASVNLTTVGLKALDLLLTSGKITLLILDEENDIFLLIFDAMRTFSASDEVQKL
GCKVLHVLFERVSEEQLTEFVENKDYMILLSALKNFEDEEEIVLHVLHCLHSLAIPCSNV
EVLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
QQYSENAVLQIAALSCLALLTETIFLNQDLEEKNENQENDNDEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHMHSPEVAESGCKMLNHLFEERSTSLDTM
AAVVPKIITVMKSHETSLSVQLEALRAMLHFIVPGIPEEYREDTEYQHKLNMIEKQCFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIIHFPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCMGTGHLLAKILISTLQRFKDIGEVQIKGFQTVLTMLELSV
SFSKLLVHYSFDSVIFHQLSSSITEQKDQQFLNLCCKCFAKLAIDNELKSVMLEKACDQN
NSIMVECLLLLGADANRAKEATSLICQVCEKASSPKLVELLLNSGSREQDVRKALTISIG
KGNSQIISLLLRRLALDLANNSICLGGFCMGKIDPSWLGPLFPDKTSYLRKETNVGSTLA
RMVLRYQMKSSVEEEAGSGSNGNFSEEMVDKFDEWTFVPESYIDSVFGQSDDLDSEGSEG
SFLVKKKSNSISVGEFYGDPALQRCSPNLQRHSSSLGPVFDHEDLIKRKRKIFSSDDSLR
ASKFQSHMKHSESMSSLPSEREYITSLDLSANELKDVDALSQNSCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPTYLLKMNCIANLDVSRNDIGPSVVLDPAV
KCPTLKQFNLSYNQISSLPANLGDVVEKLEQLILEGNKISEICSPLSLKELKILNLSKNQ
ISSLSEDFLETCPKMEILSAKMNFLAAMPFLPSSITSLKLSQNRFTCVPEAILHLPHLRS
LDMSSNDIRYLPGPVHWRSLNLRELLFSHNQISILDLSEKACAWSRIEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKIKKSDLGMQGATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVTDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGFPK
HPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGREQALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDHHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDHLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKTSLTRTLQHRIVLHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRRISIPKSFTVECMVATSH
NSKNVRIWLGCGHTDKGQLSFLDLNTERYTSEEVTDSRILCLALVYLPVEKESWIVSGTQ
SGMLLVINTEDGRKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGNLVIFEDKSV
KCKGATPLKILNIGNVSTPLMCLSESVNLTEKNIMWGGCGTKVFSFSDDFTIQKLIETRT
NQRFSYASFCDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEELVRV
SKELKHKMCYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLGSLKNVMLVLGYNRKSAEGTQHQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAEK
MRRTSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgccaggggtgcgaggaggaggacgaggaatctctgaagaagttg
atagttaggctgaacaatgtccaggaaggaaaacagatagagacgctggttcaaatcctg
gaggatatgctggtgtttacttacgccgatcacgcctccaagttatttcaagacaaaaat
gtccacgtgcctctgttgatcgtcttggactcctatatgagagtcgctagtgtgcagcag
gtgggttggtcacttttatgcaaattaatagaaatctgtccaaatacaatgcaaagctta
atgggaccccatgatattggacatgattgggaagtccttggggttcaccaattgattctt
aaaatgctaacagttcataatgccagtgtcaacctgacaacagttggattgaaggcctta
gatcttctcctaacttcaggtaaaatcactttgctgatattggatgaagaaaatgatatt
ttcttgttaatcttcgatgccatgcgcacattttcagccagtgatgaagtccagaaactt
ggatgtaaagttttacatgtgctgtttgagagagtttcagaggagcaactgactgaattt
gttgagaataaagattatatgatattgctcagtgcgttaaaaaattttgaagatgaagag
gaaattgtgctccatgtactgcactgtttacattccttagcaattccttgtagtaatgtt
gaagtcctcatgagtggcaatgtcaggtgttacaatattgtggtagaagccatgaaagca
ttccctatcagtgaaaaaattcaagaagtaagttgctgcttgctccataggcttacgtta
ggtaatttttttaatatcctggtattaaatgaggtgcatgagtttgtggtgaaggccgtg
cagcagtattcagagaacgcagtattacaaatcgcagcactcagctgtttagcgctcctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgac
aatgatgaagaagataaattgttttggctggaagcctgttacaaagcattaacttggcat
agaaagaacaagcatgtgcaggaggctgcctgttgggccctgaataatctccttatgtat
cagaacagtttacacgagaagatcggagatgaagatggccagttcccagctcacagggaa
gtgatgctgtccatgctgatgcactcttcatcaaaagaagtcttccaggcatctgcaaat
gctttgtcaactctgttagaacaaaatgttaattttagaaagatcctgttgtccaaagga
atatatctgaatgtgttggagttaatgcagaagcatatgcattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatcttttcgaagaaaggagcacttccctggatacaatg
gcagcagtggtccccaaaataataaccgtcatgaaaagtcatgagacatcgttatcagtg
cagctggaggcacttcgagctatgttacattttatagttccaggcatcccggaagaatac
agggaagatactgaatatcagcataagctaaatatgattgaaaagcagtgtttcaggaat
gatattcacaaattggtcctggcagctttgaacaggttcattggaaatcctgggattcag
aagtgtggattaaaagtaatatcatctataatacattttcctgatgcattagaggtatta
tccctggaaggtgctattgattcggtgcttcatacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgtttgattacaaagaagaatttatgc
atgggaactgggcatctgttggcaaaaattctgatttccaccctacaacgatttaaggat
attggtgaagtacagataaaaggatttcagacagtcttgacgatgctggaattgtcagtg
tccttttccaagctactggtgcattactcctttgattcagtaatattccatcagttgtcc
tccagtatcacggagcaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattggccattgataatgagttaaaaagtgtgatgctggagaaagcatgtgatcagaat
aacagcatcatggttgaatgcctgcttctgttgggagcagatgccaatcgagcaaaagaa
gcaacttctttgatttgtcaggtatgtgagaaagcaagcagtcccaaactggtagaattg
ttactgaatagtggatctcgtgagcaggatgttcggaaagctctgacaatcagcattggg
aaaggcaacagccaaataatcagcttactcttgaggaggcttgccctggatctggccaat
aatagcatctgtcttggaggattttgtatgggaaaaattgacccttcctggcttggtcct
ttatttccagataagacatcttatttaagaaaagagacaaatgtaggatccaccctggca
aggatggtgctcagatatcagatgaaaagttctgtggaggaagaagctggctcaggcagc
aatgggaatttttcagaagaaatggttgataaatttgatgaatggaccttcgttcctgag
tcttacattgacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagtgtaggagaattttacggagatcct
gccttgcagcgttgctcaccaaatttgcaaagacattccagttcattgggacccgttttt
gatcatgaagatttaataaagagaaaaagaaaaatattttcatcagatgattcactcaga
gcatcaaaattccagtcccatatgaagcattcagagagcatgtcttccctgccttctgag
agagaatatattacatcattagacctttcagcaaatgaactaaaagatgttgatgccctg
agccagaactcctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcgctcacaagttttccacaacaactatgtgaaactctgaaatgtttaacacatttg
gatctgcatagtaataaatttacatcatttcccacttacttgttgaaaatgaattgtatt
gctaaccttgatgtctctcgaaatgacattggaccctcggtagttttggaccctgctgtg
aagtgcccgaccttgaaacagtttaacttgtcgtataatcagatatcttctcttcctgcg
aaccttggtgatgtggtagagaaattggaacagctcattttagaaggaaataaaatatca
gaaatatgttcccctttgagcctgaaggaactgaagattttaaaccttagtaaaaaccag
atttcatctttatcagaggacttccttgagacttgtcctaaaatggagattttaagtgcc
aaaatgaattttcttgctgctatgccttttttgccttcttctatcacaagcctaaaatta
tctcaaaacagattcacgtgtgtcccagaagcaattttacatctcccacacctgcggtcc
ttagatatgagcagcaatgatattcgatatctaccaggtcctgtgcactggagatctttg
aacttaagggaactcttgtttagtcataatcagatcagtatcttggacttgagtgaaaaa
gcatgtgcatggtctagaatagagaaactacatctttctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctcttgatgttagttacaacttggaa
ctgagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcatcttaattttgattttaaacatgtaggatgtaaagccaaagacatcataagg
tttcttcagcagcggttgaaaaaggctgtgccctataaccgaatgaaacttatgattgtg
ggaaatactgggagtggcaagaccaccttattgcagcaattaatgaaaatcaagaaatca
gatcttgggatgcaaggtgccacagttggcatcgatgtgaaagactggcccatccaaata
agaggcaaagggaagaaggacctcattctgaatgtatgggattttgcaggtcgtgaggaa
ttctacagcactcatccccactttatgacccaacgagccttgtatcttgcggtctatgac
ctcagcaaagggcaagcagaagttgatgccatgaagccttggcttttcaatataaaggcc
cgtgcttcttcttcccctgtgattcttgttggcacacatttagatgttactgatgagaag
cagcgcaaagcctgtatcagtaaaattaccaaggaactcttgaacaaacgagggtttcct
gcaatacgagattaccactttgtgaatgccactgaggaatccgatgctttggcaaaactt
cggaaaaccatcatcaatgagagccttaatttcaagatccgagatcagcctgttgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttatcagagcgtaaaaat
gtgccaattgaatttcctgtaattgaccggaaacgattattacaacttgtgagagaacat
cagctgcagttagatgaaaatgagcttcctcatgcagttcactttctaaatgaatcaggg
gtccttcttcattttcaagacccagcactgcagttaagtgacttatattttgtagaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctttccaaaa
catcctaagggaattatttcacgcagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatggcacagtactttaaactcctagaaaaattccagattgccttg
ccaattggagaagagtatttactggttccaagcagtttgtctgaccacaggcctgtaata
gagcttccccattgtgagaactctgaaattatcattcgactgtatgaaatgccttatttt
ccaatgggcttttggtcgagattaatcaatcggttgcttgaaatttcaccttacatgctt
tcaggaagagaacaagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttactgcttggtaggatctgaagttttagatcatcacccagag
agtttcttaaaaattacagttccctcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaagagtggtttcctggattattggagattgatatt
tgtggtgaaggagaaactctgctgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatattgcttgaccacttgatgaagaaagcggaagaaggagacctccta
gtaaatccagatcaaccaaggctcacaattccaatatctcagattgctcctgatttgatt
ttggctgatctgcctagaaatattatgttgaataatgatgaactggaatttgaacaagct
ccagagtttctcttaggtgacggcagttttggatctgtttatcgggcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacatacatcacttaggctgttaagacaagag
ctggtggtgctctgccacctccaccatcccagcttaatatctttgctggcagctgggatt
cgtcctcgaatgttggtgatggaattagcctccaagggttccctggaccgcctgcttcag
caagacaaaaccagtcttaccagaacgctgcagcacagaatcgtgctacatgtggccgat
ggcttgagatacctccattcagctatgattatataccgtgacttgaagccccacaatgtg
ttgcttttcaccttgtatcccaatgctgccatcatcgccaagattgcggactacgggatt
gctcagtactgctgtagaatggggataaaaacatcagagggcactccaggttttcgtgca
cctgaagttgctagaggaaatgttatttataaccaacaagctgatgtttattcatttggt
ttgctactttatgacattttgacaactggaggtagaatagcagagggtttgaagtttccg
aatgagtttgatgaattggcaatacaagggaaattacccgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaagttaattaaaaaatgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcggctgagttaatctgtctg
atgagacgtatatcaatacctaaaagctttactgttgaatgcatggttgctacgagtcat
aacagcaagaatgtgaggatttggctgggctgtgggcacactgacaaaggacagctctcg
tttcttgacttaaatacagaaagatacacttctgaggaagttactgatagtagaattctg
tgccttgccttggtgtatcttcctgttgaaaaggaaagttggattgtgtctggaacacag
tctggcatgctcctcgtcattaatactgaagatgggagaaagaggcatacccttgaaaag
atgactgattctgttacttgcttgtattgcaattccttttccaagcaaagcaagcagaaa
aatttccttttagtgggaactgctgatggcaacttagtgatttttgaagataaaagtgtt
aagtgtaaaggagccactcctttgaagatactcaacataggaaatgtcagcactccactg
atgtgtttgagtgaatctgtgaacttaactgaaaaaaacattatgtggggaggatgtggt
acaaaagttttctcattttctgatgatttcaccattcaaaaactcattgagaccaggaca
aatcagcgattttcctatgcatctttctgtgattccaacatcatagcagtggtagtagac
acggctctttatgttgctaagaaaaatagcccatttgtggaagtgtgggataagaagact
gaaaaactctgtgaactaatagattgtgtgcactttttaaaggaggaactggtcagagta
agcaaggaattgaaacacaaaatgtgttattctgggagagtgaagactctctgcctccag
aagaacactgctctctggataggaactggaggaggccatatcttactccttgatctttca
actcgtcggattatacgtataattcacaacttttgtgattctgttagagtcatgatgact
gcacagttaggaagccttaaaaatgtcatgctggttttggggtataaccggaaaagtgct
gaaggtacacaacaccaaaaagagatacagtcttgcttgtctgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtaagaaaagaattagctgaaaaa
atgagaagaacatctgttgaataa
DBGET
integrated database retrieval system
