KEGG   Bubalus bubalis (water buffalo): 102409665
Entry
102409665         CDS       T05912                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X3
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub01522  Endocrine resistance
bbub04010  MAPK signaling pathway
bbub04015  Rap1 signaling pathway
bbub04068  FoxO signaling pathway
bbub04071  Sphingolipid signaling pathway
bbub04114  Oocyte meiosis
bbub04148  Efferocytosis
bbub04218  Cellular senescence
bbub04261  Adrenergic signaling in cardiomyocytes
bbub04370  VEGF signaling pathway
bbub04380  Osteoclast differentiation
bbub04550  Signaling pathways regulating pluripotency of stem cells
bbub04611  Platelet activation
bbub04613  Neutrophil extracellular trap formation
bbub04620  Toll-like receptor signaling pathway
bbub04621  NOD-like receptor signaling pathway
bbub04622  RIG-I-like receptor signaling pathway
bbub04625  C-type lectin receptor signaling pathway
bbub04657  IL-17 signaling pathway
bbub04658  Th1 and Th2 cell differentiation
bbub04659  Th17 cell differentiation
bbub04660  T cell receptor signaling pathway
bbub04664  Fc epsilon RI signaling pathway
bbub04668  TNF signaling pathway
bbub04670  Leukocyte transendothelial migration
bbub04714  Thermogenesis
bbub04722  Neurotrophin signaling pathway
bbub04723  Retrograde endocannabinoid signaling
bbub04728  Dopaminergic synapse
bbub04750  Inflammatory mediator regulation of TRP channels
bbub04912  GnRH signaling pathway
bbub04914  Progesterone-mediated oocyte maturation
bbub04917  Prolactin signaling pathway
bbub04926  Relaxin signaling pathway
bbub04932  Non-alcoholic fatty liver disease
bbub04933  AGE-RAGE signaling pathway in diabetic complications
bbub04935  Growth hormone synthesis, secretion and action
bbub04936  Alcoholic liver disease
bbub05014  Amyotrophic lateral sclerosis
bbub05020  Prion disease
bbub05022  Pathways of neurodegeneration - multiple diseases
bbub05132  Salmonella infection
bbub05133  Pertussis
bbub05135  Yersinia infection
bbub05140  Leishmaniasis
bbub05142  Chagas disease
bbub05145  Toxoplasmosis
bbub05152  Tuberculosis
bbub05161  Hepatitis B
bbub05163  Human cytomegalovirus infection
bbub05167  Kaposi sarcoma-associated herpesvirus infection
bbub05169  Epstein-Barr virus infection
bbub05170  Human immunodeficiency virus 1 infection
bbub05171  Coronavirus disease - COVID-19
bbub05205  Proteoglycans in cancer
bbub05208  Chemical carcinogenesis - reactive oxygen species
bbub05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bbub05415  Diabetic cardiomyopathy
bbub05417  Lipid and atherosclerosis
bbub05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102409665 (MAPK12)
   04015 Rap1 signaling pathway
    102409665 (MAPK12)
   04370 VEGF signaling pathway
    102409665 (MAPK12)
   04668 TNF signaling pathway
    102409665 (MAPK12)
   04068 FoxO signaling pathway
    102409665 (MAPK12)
   04071 Sphingolipid signaling pathway
    102409665 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    102409665 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102409665 (MAPK12)
   04218 Cellular senescence
    102409665 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    102409665 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102409665 (MAPK12)
   04613 Neutrophil extracellular trap formation
    102409665 (MAPK12)
   04620 Toll-like receptor signaling pathway
    102409665 (MAPK12)
   04621 NOD-like receptor signaling pathway
    102409665 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    102409665 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    102409665 (MAPK12)
   04660 T cell receptor signaling pathway
    102409665 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    102409665 (MAPK12)
   04659 Th17 cell differentiation
    102409665 (MAPK12)
   04657 IL-17 signaling pathway
    102409665 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    102409665 (MAPK12)
   04670 Leukocyte transendothelial migration
    102409665 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    102409665 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    102409665 (MAPK12)
   04917 Prolactin signaling pathway
    102409665 (MAPK12)
   04926 Relaxin signaling pathway
    102409665 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    102409665 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102409665 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    102409665 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    102409665 (MAPK12)
   04722 Neurotrophin signaling pathway
    102409665 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102409665 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102409665 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    102409665 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    102409665 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    102409665 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102409665 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102409665 (MAPK12)
   05161 Hepatitis B
    102409665 (MAPK12)
   05171 Coronavirus disease - COVID-19
    102409665 (MAPK12)
   05163 Human cytomegalovirus infection
    102409665 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102409665 (MAPK12)
   05169 Epstein-Barr virus infection
    102409665 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102409665 (MAPK12)
   05135 Yersinia infection
    102409665 (MAPK12)
   05133 Pertussis
    102409665 (MAPK12)
   05152 Tuberculosis
    102409665 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102409665 (MAPK12)
   05140 Leishmaniasis
    102409665 (MAPK12)
   05142 Chagas disease
    102409665 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    102409665 (MAPK12)
   05020 Prion disease
    102409665 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    102409665 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102409665 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    102409665 (MAPK12)
   05415 Diabetic cardiomyopathy
    102409665 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    102409665 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    102409665 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102409665 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    102409665 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bbub01001]
    102409665 (MAPK12)
Enzymes [BR:bbub01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     102409665 (MAPK12)
Protein kinases [BR:bbub01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   102409665 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 102409665
NCBI-ProteinID: XP_006066392
EnsemblRapid: ENSBBUG00015014546
LinkDB
Position
4:442862..450877
AA seq 367 aa
MSSPSPARKGFYRQEVTKTAWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRVQFLVYQTLKGLKYIHAAGVIHRDLKPSNLAVNEDCELKILDFGLARQADT
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSMGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASVLTNASPLAVSLLEKMLVLDAERRV
TAAEALAHPYFESLHDTEDEPQAEKYDESFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgtcgcccgcccgcaagggcttttatcgccaggaggtgaccaagacggcc
tgggaggtgcgcgtcgtgtaccaggatctgcagcccgtgggctcgggcgcctacggcgcc
gtgtgctcggcggtggacagccgcacgggcgccaaggtggccatcaagaagctgtaccgg
ccctttcagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctgaagcac
atgcgccacgagaacgtgattgggctgctggacgtgttcacgcccgatgagacgctggat
gacttcacggacttctacctggtgatgccgttcatgggcaccgacctgggaaagctcatg
aagcacgagaagctgagcgaggaccgggtgcagttcctcgtctaccagacactcaagggg
ctgaagtacatccacgctgccggcgtcatccacagggacttgaagcccagcaacttggct
gtgaacgaggactgtgagctgaagatcctggacttcggcctggcccggcaggcagacacc
gagatgactggctacgtggtgacccggtggtaccgcgcacccgaggtcatcttgaactgg
atgcactacacgcagacagtggacatctggtccatgggctgcatcatggccgagatgatc
acggggaagacgctcttcaaaggcagcgaccacctggaccagctgaaggagatcatgaag
gtgacggggacgcctccagcggagtttgtgcagaggctgcaaagtgacgaggccaagaac
tacatgaagggcctccctgagctggagaagaaggattttgcctccgtcctgaccaacgcg
agccccctggccgtgagcctcctggagaaaatgctggtgctggacgcggagcggcgggtg
acggcggccgaggcgctggcccacccctactttgagtcgctgcacgacacggaggacgag
ccccaggccgagaagtatgatgagtcctttgacgatgtggaccgcacgctggatgagtgg
aagcgtgtcacatataaagaggtgctcagcttcaagcctccccggcagctgggggccaag
gtctccaaggagacagccttgtga

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