Bos mutus (wild yak): 102285300 Help Entry 102285300         CDS       T02919                                  Symbol PLCG2 Name (RefSeq) phospholipase C gamma 2   KO K05859   phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11] Organism bom  Bos mutus (wild yak) Pathway bom00562   Inositol phosphate metabolism bom01100   Metabolic pathways bom01521   EGFR tyrosine kinase inhibitor resistance bom04012   ErbB signaling pathway bom04014   Ras signaling pathway bom04020   Calcium signaling pathway bom04062   Chemokine signaling pathway bom04064   NF-kappa B signaling pathway bom04066   HIF-1 signaling pathway bom04070   Phosphatidylinositol signaling system bom04072   Phospholipase D signaling pathway bom04360   Axon guidance bom04370   VEGF signaling pathway bom04380   Osteoclast differentiation bom04611   Platelet activation bom04613   Neutrophil extracellular trap formation bom04625   C-type lectin receptor signaling pathway bom04650   Natural killer cell mediated cytotoxicity bom04662   B cell receptor signaling pathway bom04664   Fc epsilon RI signaling pathway bom04666   Fc gamma R-mediated phagocytosis bom04670   Leukocyte transendothelial migration bom04722   Neurotrophin signaling pathway bom04750   Inflammatory mediator regulation of TRP channels bom04919   Thyroid hormone signaling pathway bom04933   AGE-RAGE signaling pathway in diabetic complications bom04935   Growth hormone synthesis, secretion and action bom05167   Kaposi sarcoma-associated herpesvirus infection bom05169   Epstein-Barr virus infection bom05170   Human immunodeficiency virus 1 infection bom05171   Coronavirus disease - COVID-19 bom05200   Pathways in cancer bom05205   Proteoglycans in cancer bom05206   MicroRNAs in cancer bom05214   Glioma bom05223   Non-small cell lung cancer bom05225   Hepatocellular carcinoma Module bom_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:bom00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102285300 (PLCG2)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     102285300 (PLCG2)    04014 Ras signaling pathway     102285300 (PLCG2)    04370 VEGF signaling pathway     102285300 (PLCG2)    04064 NF-kappa B signaling pathway     102285300 (PLCG2)    04066 HIF-1 signaling pathway     102285300 (PLCG2)    04020 Calcium signaling pathway     102285300 (PLCG2)    04070 Phosphatidylinositol signaling system     102285300 (PLCG2)    04072 Phospholipase D signaling pathway     102285300 (PLCG2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102285300 (PLCG2)    04613 Neutrophil extracellular trap formation     102285300 (PLCG2)    04625 C-type lectin receptor signaling pathway     102285300 (PLCG2)    04650 Natural killer cell mediated cytotoxicity     102285300 (PLCG2)    04662 B cell receptor signaling pathway     102285300 (PLCG2)    04664 Fc epsilon RI signaling pathway     102285300 (PLCG2)    04666 Fc gamma R-mediated phagocytosis     102285300 (PLCG2)    04670 Leukocyte transendothelial migration     102285300 (PLCG2)    04062 Chemokine signaling pathway     102285300 (PLCG2)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     102285300 (PLCG2)    04919 Thyroid hormone signaling pathway     102285300 (PLCG2)   09156 Nervous system    04722 Neurotrophin signaling pathway     102285300 (PLCG2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102285300 (PLCG2)   09158 Development and regeneration    04360 Axon guidance     102285300 (PLCG2)    04380 Osteoclast differentiation     102285300 (PLCG2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102285300 (PLCG2)    05206 MicroRNAs in cancer     102285300 (PLCG2)    05205 Proteoglycans in cancer     102285300 (PLCG2)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     102285300 (PLCG2)    05214 Glioma     102285300 (PLCG2)    05223 Non-small cell lung cancer     102285300 (PLCG2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102285300 (PLCG2)    05171 Coronavirus disease - COVID-19     102285300 (PLCG2)    05167 Kaposi sarcoma-associated herpesvirus infection     102285300 (PLCG2)    05169 Epstein-Barr virus infection     102285300 (PLCG2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102285300 (PLCG2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102285300 (PLCG2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:bom04131]     102285300 (PLCG2) Enzymes [BR:bom01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      102285300 (PLCG2) Membrane trafficking [BR:bom04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     102285300 (PLCG2)  Endocytosis   Macropinocytosis    Phospholipase C     102285300 (PLCG2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y C2 SH3_1 SH3_9 PH PH_12 SH2_1 SH3_2 PH_14 EF-hand_like GDPD Motif Other DBs NCBI-GeneID:  102285300 NCBI-ProteinID:  XP_005907337 LinkDB All DBs Position Un AA seq 1221 aa AA seqDB search MAQALLETGRVFCWAPFFCWWNWEPAWGVLELHWRGLDRVAQPAGLQEAPLRWRMPSVIC GWWLVDDGLSELLLPILDIMEIKEIRPGKSSKDFERAKAVRQKEECCFTVLYGSQFILST LSLAADSKEDAAKWLSGLKILHQEVMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKT ILPLVNFKVSSAKFLKDKFLEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF LLGNTDRPDASAVHLHDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAETFLFVD EFLTYLFSRENSIWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRC LRMGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEH CCVEQQRHMARVFKEVFGDLLLTKPKEASADQLPSPSQLRGKIIIKHKKLGPRGDVDVNM EDKKDEHKQQGELHMWDPIDQKWTRHYCAVADAKLSFSDDIEQTVEEELPLDIPPTELHF GEKWFHKKVEKRTSAEKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRI RSTMEGGTMKYYLTDNLMFTSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYY DGLSRGEAEDMLMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSA YFESLVELVSYYEKHALYRKMKLRYPVTPELLERYNTERDINSLYDVSRMYVDPSEINPS MPQRTVKALYDYRAKQSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDIS PTEGEEVDKQIIEDNPLGSLCRGILNLNIYNVVKAPHGKNQKPFVFILEPKKQGDPPVEF ATDSVEELFEWFQSIREITWKMDAKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLE NPDFREIRSFVETKADSIVRQKPSDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQ MVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKIQMTLTVKVL GARHLPKPGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWTPTQEKVTFEIYDPN LAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRP VLVSGETPVGARRATSAAEGG NT seq 3666 nt NT seq  +upstreamnt  +downstreamnt atggcccaggccctgctggagactgggagagtgttctgctgggctcccttcttctgctgg tggaactgggagcctgcctggggagtgctggagctgcactggcggggcttggaccgggtc gcccagcctgccgggctgcaggaggcccctctgaggtggcggatgccgagtgtcatctgt ggctggtggctggtggacgatggcctgtcagagttgctgctgcctatattggacatcatg gagataaaggagatccggccggggaagagctccaaggatttcgagcgcgcgaaagcggtc cgccagaaggaagaatgctgcttcaccgtcctgtacggctcccagtttatcctcagcacg ctcagcctggcagctgactcgaaggaggatgccgctaagtggctgtctggcctgaagatc ttacaccaggaagtgatgagcgcgtccacccccaccatcatcgagagctggctgagaaag cagatttattctgtggatcaaaccaggagaaacagcatcagcctccgggagttgaagacc atcttgcctctggtcaacttcaaagtgagcagtgccaagttcctcaaagataagttcctg gaaataggcgcacacaaagatgaactcagctttgaacagttccatctcttctataaaaaa cttatgtttgaacagcaaaaatcgatccttgacgaattcaaaaaggattcctccgtgttc ctcttgggcaacaccgaccggccagacgcctctgctgtccacctgcacgacttccagcgg tttctcttgcatgaacagcaggagctttgggctcaggatctgaacaaagtccgtgagcgg atgacgaagtttattgacgacaccatgagggaaactgctgaaaccttcctgtttgtggat gagttcctcacgtacctgttttcccgggagaacagcatctgggacgaaaagtacgacgtg gtggacatgcaggacatgaacaaccccttgtctcattactggatctcctcgtctcacaac acgtacctcacgggggaccagctgcggagcgagtcgtccacggaggcctacatccgctgc ctgcggatgggctgccgctgcatcgagctggactgctgggacgggcccgacggcaagccc atcatctaccacggctggacgcggaccaccaagatcaagttcgacgacgttgtgcaggcc atcaaagaccacgcctttgtcacctccagcttccctgtgatcctgtccatcgaggagcac tgctgtgtggagcagcagcgccacatggccagggtgttcaaggaagtgtttggagacctg ctgctgaccaaacctaaggaggccagtgccgaccagctgccgtcgcccagccagctgcgc gggaagatcatcatcaagcataagaagctgggcccccgcggtgacgtggatgtcaacatg gaggacaagaaggacgagcacaagcagcagggcgaactgcacatgtgggaccccatcgac cagaaatggactcggcactactgtgccgttgctgatgccaagctgtccttcagcgatgac attgaacagactgtggaagaggagctgcccctggatatacccccaacagagctgcatttt ggggagaagtggttccacaagaaggtggagaagaggacaagtgccgagaagctgctgcag gaatactgtgccgagacagggggcaaggatgggaccttcttggtgcgggagagtgagacc ttccccaacgactacaccttgtccttctggcggtcgggccgcgtgcagcactgccggatc cgctccaccatggagggcgggaccatgaagtactacctgaccgacaacctcatgttcacc agcatctacgctctcatccagcactaccgcgagacacacctgcgctgcgccgagttcgag ctccggctgaccgaccccgtgcccaaccccaacccgcacgagtccaagccgtggtactac gatgggctgagccgtggagaagcggaggacatgctgatgcggatcccccgggatggggcc ttcctgatccggaagcgggaaggtaccgactcctatgccatcaccttcagggccaggggc aaggtgaagcactgtcgcatcaaccgagacggccggcacttcgtgctgggcacctccgcc tacttcgagagccttgtggagctggtcagctactacgagaagcacgcactctaccggaag atgaaactgcgctaccccgtgacccccgagctcctggagcgctacaacacggaaagagat ataaactccctctacgatgtcagcaggatgtatgtggatcccagtgaaatcaatccttca atgcctcagagaaccgtgaaagctctgtatgactacagggccaagcagagtgacgagctg agcttttgccgcggtgccctcatccacaacgtctccaaggagcctgggggctggtggaaa ggagactatgggaccagaatccagcagtacttcccgtccaattacgtcgaggacatttca ccaacagaaggggaggaggtggataagcagattattgaagacaatcccttagggtccctt tgcagaggaatcctgaatctcaacatctataatgttgtaaaagccccacatgggaagaac cagaagcctttcgtctttatcttggagcccaagaagcagggcgaccctccggtagagttt gccacggacagcgtggaggagctgtttgagtggttccagagcatccgggagatcacctgg aagatggacgccaaggagaacaacatgaagtactgggagaagaaccagtccatcgccatc gagctctcggacctggtcgtctactgcaagccaaccagcaagaccaaggacaacctcgaa aaccctgacttccgagaaatccgctccttcgtggagacgaaggctgacagtatcgtcaga cagaagcccagcgatctcctgaaatacaatcaaaagggcctgacccgtgtgtaccccaaa ggacagcgggtggactcgtccaactatgaccccttccgcctctggctgtgcggctcccag atggtggcactcaatttccagactccagataagtacatgcagatgaaccacgccctgttc tccctcaacgggcggacgggctacgtcctgcagcctgagagcatgagggcggagaagtac gaccccatgccacccgagtcccagaggaagatccagatgaccctgacggtcaaggtgctg ggggcccgtcacctccccaagcccggccgcagcatcgcgtgccccttcgtggaggtggag atatgcggagcggagtacgacagcaacaagtttaagacgacggttgtgaatgacaatggc ctcagccctgtttggaccccaacgcaggagaaggtgacgtttgagatttatgaccccaac cttgcgtttctgcgctttgtggtttatgaggaagatatgttcagcgatcccaactttctg gcccatgccacgtaccccattaaaggaatcaagtcaggatttagatctgttcctctgaag aacggctacagtgaagacattgagctggcgtccctcctggttttctgtgagatgcggcca gtcctggtgagtggagaaacaccagtgggtgctcgcagagccacgtctgcggcggagggg gggtga

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