KEGG   Bos mutus (wild yak): 102285848
Entry
102285848         CDS       T02919                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
bom  Bos mutus (wild yak)
Pathway
bom01522  Endocrine resistance
bom04010  MAPK signaling pathway
bom04015  Rap1 signaling pathway
bom04068  FoxO signaling pathway
bom04071  Sphingolipid signaling pathway
bom04114  Oocyte meiosis
bom04148  Efferocytosis
bom04218  Cellular senescence
bom04261  Adrenergic signaling in cardiomyocytes
bom04370  VEGF signaling pathway
bom04380  Osteoclast differentiation
bom04550  Signaling pathways regulating pluripotency of stem cells
bom04611  Platelet activation
bom04613  Neutrophil extracellular trap formation
bom04620  Toll-like receptor signaling pathway
bom04621  NOD-like receptor signaling pathway
bom04622  RIG-I-like receptor signaling pathway
bom04625  C-type lectin receptor signaling pathway
bom04657  IL-17 signaling pathway
bom04658  Th1 and Th2 cell differentiation
bom04659  Th17 cell differentiation
bom04660  T cell receptor signaling pathway
bom04664  Fc epsilon RI signaling pathway
bom04668  TNF signaling pathway
bom04670  Leukocyte transendothelial migration
bom04714  Thermogenesis
bom04722  Neurotrophin signaling pathway
bom04723  Retrograde endocannabinoid signaling
bom04728  Dopaminergic synapse
bom04750  Inflammatory mediator regulation of TRP channels
bom04912  GnRH signaling pathway
bom04914  Progesterone-mediated oocyte maturation
bom04917  Prolactin signaling pathway
bom04926  Relaxin signaling pathway
bom04932  Non-alcoholic fatty liver disease
bom04933  AGE-RAGE signaling pathway in diabetic complications
bom04935  Growth hormone synthesis, secretion and action
bom04936  Alcoholic liver disease
bom05014  Amyotrophic lateral sclerosis
bom05020  Prion disease
bom05022  Pathways of neurodegeneration - multiple diseases
bom05132  Salmonella infection
bom05133  Pertussis
bom05135  Yersinia infection
bom05140  Leishmaniasis
bom05142  Chagas disease
bom05145  Toxoplasmosis
bom05152  Tuberculosis
bom05161  Hepatitis B
bom05163  Human cytomegalovirus infection
bom05167  Kaposi sarcoma-associated herpesvirus infection
bom05169  Epstein-Barr virus infection
bom05170  Human immunodeficiency virus 1 infection
bom05171  Coronavirus disease - COVID-19
bom05205  Proteoglycans in cancer
bom05208  Chemical carcinogenesis - reactive oxygen species
bom05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
bom05415  Diabetic cardiomyopathy
bom05417  Lipid and atherosclerosis
bom05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:bom00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102285848 (MAPK12)
   04015 Rap1 signaling pathway
    102285848 (MAPK12)
   04370 VEGF signaling pathway
    102285848 (MAPK12)
   04668 TNF signaling pathway
    102285848 (MAPK12)
   04068 FoxO signaling pathway
    102285848 (MAPK12)
   04071 Sphingolipid signaling pathway
    102285848 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    102285848 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102285848 (MAPK12)
   04218 Cellular senescence
    102285848 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    102285848 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102285848 (MAPK12)
   04613 Neutrophil extracellular trap formation
    102285848 (MAPK12)
   04620 Toll-like receptor signaling pathway
    102285848 (MAPK12)
   04621 NOD-like receptor signaling pathway
    102285848 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    102285848 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    102285848 (MAPK12)
   04660 T cell receptor signaling pathway
    102285848 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    102285848 (MAPK12)
   04659 Th17 cell differentiation
    102285848 (MAPK12)
   04657 IL-17 signaling pathway
    102285848 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    102285848 (MAPK12)
   04670 Leukocyte transendothelial migration
    102285848 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    102285848 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    102285848 (MAPK12)
   04917 Prolactin signaling pathway
    102285848 (MAPK12)
   04926 Relaxin signaling pathway
    102285848 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    102285848 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102285848 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    102285848 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    102285848 (MAPK12)
   04722 Neurotrophin signaling pathway
    102285848 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102285848 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102285848 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    102285848 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    102285848 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    102285848 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102285848 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102285848 (MAPK12)
   05161 Hepatitis B
    102285848 (MAPK12)
   05171 Coronavirus disease - COVID-19
    102285848 (MAPK12)
   05163 Human cytomegalovirus infection
    102285848 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102285848 (MAPK12)
   05169 Epstein-Barr virus infection
    102285848 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102285848 (MAPK12)
   05135 Yersinia infection
    102285848 (MAPK12)
   05133 Pertussis
    102285848 (MAPK12)
   05152 Tuberculosis
    102285848 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102285848 (MAPK12)
   05140 Leishmaniasis
    102285848 (MAPK12)
   05142 Chagas disease
    102285848 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    102285848 (MAPK12)
   05020 Prion disease
    102285848 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    102285848 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102285848 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    102285848 (MAPK12)
   05415 Diabetic cardiomyopathy
    102285848 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    102285848 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    102285848 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102285848 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    102285848 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:bom01001]
    102285848 (MAPK12)
Enzymes [BR:bom01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     102285848 (MAPK12)
Protein kinases [BR:bom01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   102285848 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 102285848
NCBI-ProteinID: XP_005903977
LinkDB
Position
Un
AA seq 346 aa
MPVWVAFWPVTEAGPHARPCSSAYDTRLRQRVAVKKLSRPFQSLIHARRTYRELRLLKHL
KHENVIGLLDVFTPDETLDDFMDFYLVMPFMGTDLGKLMKHEKLSEDRVQFLVYQTLKGL
KYIHAAGVIHRDLKPSNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM
HYTQTVDIWSVGCIMAEMITGKTLFKGNDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY
MKGLPELEKKDFASVLTNASPLAVSLLEKMLVLDAERRVTAAEALAHPYFESLHDTEDDP
QAEKYDESFDDMDRTLDEWKRVTYKEVLSFKPPRQLGAKVSKETAL
NT seq 1041 nt   +upstreamnt  +downstreamnt
atgcccgtgtgggtggccttctggccagtcaccgaggcggggcctcacgcgcggccttgc
agctcggcctacgacacgcggctgcgccagagggtggcggtgaagaagctgtcgcggccc
ttccagtctctgatccatgcgcggaggacctaccgggagctgcggctgctcaaacacctg
aagcacgagaacgtgattgggctgctggacgtgttcacgcccgatgagacgctggatgac
ttcatggacttctacctggtgatgccgttcatgggcaccgacctgggaaagctcatgaag
cacgagaagctgagcgaggaccgggtgcagttcctcgtctaccagacgctcaaggggctg
aagtacatccacgctgccggcgtcatccacagggacctgaagcctagcaacctggctgtg
aacgaggactgtgagctgaagatcctggactttggcctggcccggcaggcagacagcgag
atgaccggctacgtggtgacccggtggtaccgcgcgcccgaggtcatcttgaactggatg
cactacacgcagacggtggacatctggtccgtgggctgcatcatggccgagatgatcacg
gggaagacactcttcaaaggcaacgaccacctggaccagctgaaggagatcatgaaggtg
acggggacgcctcccgcggagtttgtgcagaggctgcaaagtgatgaggccaagaactac
atgaagggcctccctgagctggagaagaaggattttgcctccgtcctgaccaacgcgagc
cccctggccgtgagcctcctggagaaaatgctggtgctggatgcggagcggcgggtgacg
gcggccgaggcgctggcccacccctactttgagtcgctgcacgacacggaggacgatccc
caggccgagaagtacgatgagtcctttgacgacatggaccgcacgctggacgagtggaag
cgtgtcacatataaagaggtgctcagcttcaagcctccccggcagctgggggccaaggtc
tccaaggagacagccttgtga

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