Bos taurus (cow): 280707
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Entry
280707 CDS
T01008
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
bta
Bos taurus (cow)
Pathway
bta00350
Tyrosine metabolism
bta00790
Folate biosynthesis
bta01100
Metabolic pathways
bta04728
Dopaminergic synapse
bta04917
Prolactin signaling pathway
bta05012
Parkinson disease
bta05030
Cocaine addiction
bta05031
Amphetamine addiction
bta05034
Alcoholism
Module
bta_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
bta00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
280707 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
280707 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
280707 (TH)
09156 Nervous system
04728 Dopaminergic synapse
280707 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
280707 (TH)
09165 Substance dependence
05030 Cocaine addiction
280707 (TH)
05031 Amphetamine addiction
280707 (TH)
05034 Alcoholism
280707 (TH)
Enzymes [BR:
bta01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
280707 (TH)
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GFIT
Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
280707
NCBI-ProteinID:
NP_776309
Ensembl:
ENSBTAG00000026768
VGNC:
35816
UniProt:
P17289
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Position
29:49383359..49391398
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AA seq
491 aa
AA seq
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MPTPNAASPQAKGFRRAVSELDAKQAEAIMSPRFVGRRQSLIQDARKEREKAEAAASSSE
SAEAGSLVERDGKAVLTLLFALRPTKPPALTRAIKVFETFEAHLHHLETRPAQPLRAGSP
PLECFVRCEVPGPVVPALLSALRRVAEDVRAAGESKVLWFPRKVSELDKCHHLVTKFDPD
LDLDHPGFSDQAYRQRRKLIAEIAFQYKQGDPIPHVEYTAEETATWKEVYSTLRGLYPTH
ACREHLEAFELLERFCGYREDRIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFR
VFQCTQYIRHASSPMHSPEPDCCHELLAHGPMLADRTFAQFSQDIGLASLGVSDEEIEKL
STLYWFTVEFGLCKQNGEVNAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAVQPYQDQT
YQPVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPHAIRRALDGVQDEM
QALAHALNAIS
NT seq
1476 nt
NT seq
+upstream
nt +downstream
nt
atgcctacccccaacgccgcctcgccgcaggccaagggcttccgcagggccgtctccgag
ctggacgccaagcaggctgaggccatcatgtccccacgcttcgtcgggaggcggcagagc
ctcatccaggacgcacgcaaggagcgggagaaggcggaggccgcggcctcatcctcggag
tccgcggaggcgggcagcctggtggagagggacgggaaggcggtgctgaccctgctgttc
gccctgcggcccaccaagccccctgcgctgacccgggctatcaaggtgtttgagacattc
gaagcccacctccaccacctggagacccgaccggcccagccactgcgggcggggagcccg
cccctggagtgcttcgtgcgctgtgaggtgcccggcccagtggtgcccgccctgctgagc
gccctgcgccgcgtggcagaagatgtgcgtgccgccggggagagcaaagtcctctggttc
ccaaggaaagtgtccgagctggacaagtgtcaccacctcgtcaccaagtttgaccctgac
ctggacttggatcatcccggcttctccgaccaggcgtaccgccagcgcaggaagctgatc
gccgagatcgccttccagtacaagcaaggcgaccccattccccacgtggagtacacagcc
gaggagacagccacctggaaggaggtctactccacgctgcggggcctgtaccccacccac
gcctgccgcgagcacctggaggccttcgagctgctggagcgcttctgcgggtaccgcgag
gaccgaatcccgcagctggaggacgtctcacgcttcctgaaggagaggaccggcttccag
ctgcggcccgtggccggcctgctgtccgcgcgggacttcctggccagcctggccttccgc
gtgttccagtgcacccagtacatccgccacgcctcctcgcccatgcactccccggagccg
gactgctgccacgagctgctggcacatggcccaatgctcgccgaccggaccttcgcgcag
ttttcccaggacatcgggctcgcatccttgggagtgtcggatgaggaaattgagaagctg
tccacgctgtactggttcaccgtggagttcgggctatgcaaacagaatggagaggtgaac
gcgtacggcgcggggctgctgtcctcctacggggagctcctgcactccctttccgaggag
cccgagatccgggccttcgaccctgatgcagcggccgtgcagccctatcaggaccagacc
taccagcccgtctacttcgtgtctgagagcttcagcgatgccaaggacaagctcaggagc
tacgcctcccgcatccagcgccccttctctgtgaagtttgacccgtacacactggccatc
gacgtgctggacagtccccacgccatccggcgcgccctggacggcgtccaggacgagatg
caggccctggcccatgctctgaacgccatcagctag
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