Bos taurus (cow): 282589
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Entry
282589 CDS
T01008
Symbol
HSD11B1
Name
(RefSeq) 11-beta-hydroxysteroid dehydrogenase 1
KO
K15680
corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:
1.1.1.146
]
Organism
bta
Bos taurus (cow)
Pathway
bta00140
Steroid hormone biosynthesis
bta00980
Metabolism of xenobiotics by cytochrome P450
bta01100
Metabolic pathways
bta05204
Chemical carcinogenesis - DNA adducts
Module
bta_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:
bta00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
282589 (HSD11B1)
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
282589 (HSD11B1)
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
282589 (HSD11B1)
Enzymes [BR:
bta01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.146 11beta-hydroxysteroid dehydrogenase
282589 (HSD11B1)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
adh_short
adh_short_C2
KR
DUF1776
THF_DHG_CYH_C
2-Hacid_dh_C
Pyr_redox_2
Shikimate_DH
Pyr_redox_3
Methyltransf_25
NAD_binding_2
FMO-like
Pyr_redox
ADH_zinc_N
Motif
Other DBs
NCBI-GeneID:
282589
NCBI-ProteinID:
NP_001116504
BGD-bta:
BT25831
Ensembl:
ENSBTAG00000015086
VGNC:
29965
UniProt:
Q8HZJ8
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All DBs
Position
16:complement(73564340..73640701)
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AA seq
292 aa
AA seq
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MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAH
VVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNH
IHYTPLGVFSNDIHLLRRTLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSIAGKIACPLV
AAYSASKFALDGFFSSLRMEYEATKVNVSITLCILGLIDTDTAMKAVAGIFNAKASPKEE
CALEIIKGGTLRQDEVYYDSSILTPLLLRNPGRKIMEFFFLKKYNMERFINN
NT seq
879 nt
NT seq
+upstream
nt +downstream
nt
atggcttttatgaaaaaatacctcctccccatcctggggatcttcttggcctactactac
tattctgcgaatgaggaattcagaccagagatgcttcgaggaaagagagtgattgtcacg
ggggccagcaagggaatcggaagagaaatggcctatcacctggcaaggatgggagcacat
gtggtagtgacagcgaggtcagaagaaagtctaaagaaggtggtatcccgctgcctggag
ctgggggcggcctcagcacactacgtggcgggcaccatggagaacatgaccttcgcagaa
caatttgttgccaaagctggagagctcgtggggggacttgacatgctcattctcaaccac
atccactacacgcctttgggggtgtttagcaatgacatccatctcttgcgcagaaccctg
gaggtcaaccttctgagttatgtggtcctgagcacagccgccttgcccatgctgaagcag
accaacgggagcattgtggtcgtctcctccatagccgggaaaatagcttgtccacttgtt
gctgcgtattctgcaagcaagtttgctctggatgggttcttctcctctctcaggatggaa
tatgaggcgaccaaggtcaatgtgtcaatcaccctctgtattcttggcctcatcgacaca
gacacagccatgaaggcagttgctgggatatttaatgcaaaagcatctccaaaggaagaa
tgtgccctggagattatcaaagggggaactctgcgccaagatgaagtatattatgacagt
tcaatcttgactcctctcctgctgagaaatccaggaaggaagatcatggaatttttcttc
ttgaagaaatataatatggaaagatttataaacaactag
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