KEGG   Cercocebus atys (sooty mangabey): 105601165
Entry
105601165         CDS       T07242                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
caty  Cercocebus atys (sooty mangabey)
Pathway
caty01521  EGFR tyrosine kinase inhibitor resistance
caty01522  Endocrine resistance
caty04010  MAPK signaling pathway
caty04012  ErbB signaling pathway
caty04014  Ras signaling pathway
caty04015  Rap1 signaling pathway
caty04022  cGMP-PKG signaling pathway
caty04024  cAMP signaling pathway
caty04062  Chemokine signaling pathway
caty04066  HIF-1 signaling pathway
caty04068  FoxO signaling pathway
caty04071  Sphingolipid signaling pathway
caty04072  Phospholipase D signaling pathway
caty04114  Oocyte meiosis
caty04140  Autophagy - animal
caty04148  Efferocytosis
caty04150  mTOR signaling pathway
caty04151  PI3K-Akt signaling pathway
caty04210  Apoptosis
caty04218  Cellular senescence
caty04270  Vascular smooth muscle contraction
caty04370  VEGF signaling pathway
caty04371  Apelin signaling pathway
caty04380  Osteoclast differentiation
caty04510  Focal adhesion
caty04540  Gap junction
caty04550  Signaling pathways regulating pluripotency of stem cells
caty04613  Neutrophil extracellular trap formation
caty04620  Toll-like receptor signaling pathway
caty04650  Natural killer cell mediated cytotoxicity
caty04660  T cell receptor signaling pathway
caty04662  B cell receptor signaling pathway
caty04664  Fc epsilon RI signaling pathway
caty04666  Fc gamma R-mediated phagocytosis
caty04668  TNF signaling pathway
caty04720  Long-term potentiation
caty04722  Neurotrophin signaling pathway
caty04725  Cholinergic synapse
caty04726  Serotonergic synapse
caty04730  Long-term depression
caty04810  Regulation of actin cytoskeleton
caty04910  Insulin signaling pathway
caty04912  GnRH signaling pathway
caty04914  Progesterone-mediated oocyte maturation
caty04915  Estrogen signaling pathway
caty04916  Melanogenesis
caty04917  Prolactin signaling pathway
caty04919  Thyroid hormone signaling pathway
caty04921  Oxytocin signaling pathway
caty04926  Relaxin signaling pathway
caty04928  Parathyroid hormone synthesis, secretion and action
caty04929  GnRH secretion
caty04934  Cushing syndrome
caty04935  Growth hormone synthesis, secretion and action
caty05010  Alzheimer disease
caty05022  Pathways of neurodegeneration - multiple diseases
caty05034  Alcoholism
caty05132  Salmonella infection
caty05135  Yersinia infection
caty05160  Hepatitis C
caty05161  Hepatitis B
caty05163  Human cytomegalovirus infection
caty05164  Influenza A
caty05165  Human papillomavirus infection
caty05166  Human T-cell leukemia virus 1 infection
caty05167  Kaposi sarcoma-associated herpesvirus infection
caty05170  Human immunodeficiency virus 1 infection
caty05200  Pathways in cancer
caty05205  Proteoglycans in cancer
caty05206  MicroRNAs in cancer
caty05207  Chemical carcinogenesis - receptor activation
caty05208  Chemical carcinogenesis - reactive oxygen species
caty05210  Colorectal cancer
caty05211  Renal cell carcinoma
caty05212  Pancreatic cancer
caty05213  Endometrial cancer
caty05214  Glioma
caty05215  Prostate cancer
caty05216  Thyroid cancer
caty05218  Melanoma
caty05219  Bladder cancer
caty05220  Chronic myeloid leukemia
caty05221  Acute myeloid leukemia
caty05223  Non-small cell lung cancer
caty05224  Breast cancer
caty05225  Hepatocellular carcinoma
caty05226  Gastric cancer
caty05230  Central carbon metabolism in cancer
caty05231  Choline metabolism in cancer
caty05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:caty00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105601165 (MAP2K1)
   04012 ErbB signaling pathway
    105601165 (MAP2K1)
   04014 Ras signaling pathway
    105601165 (MAP2K1)
   04015 Rap1 signaling pathway
    105601165 (MAP2K1)
   04370 VEGF signaling pathway
    105601165 (MAP2K1)
   04371 Apelin signaling pathway
    105601165 (MAP2K1)
   04668 TNF signaling pathway
    105601165 (MAP2K1)
   04066 HIF-1 signaling pathway
    105601165 (MAP2K1)
   04068 FoxO signaling pathway
    105601165 (MAP2K1)
   04072 Phospholipase D signaling pathway
    105601165 (MAP2K1)
   04071 Sphingolipid signaling pathway
    105601165 (MAP2K1)
   04024 cAMP signaling pathway
    105601165 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    105601165 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    105601165 (MAP2K1)
   04150 mTOR signaling pathway
    105601165 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105601165 (MAP2K1)
   04148 Efferocytosis
    105601165 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    105601165 (MAP2K1)
   04210 Apoptosis
    105601165 (MAP2K1)
   04218 Cellular senescence
    105601165 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105601165 (MAP2K1)
   04540 Gap junction
    105601165 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    105601165 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105601165 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105601165 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    105601165 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    105601165 (MAP2K1)
   04660 T cell receptor signaling pathway
    105601165 (MAP2K1)
   04662 B cell receptor signaling pathway
    105601165 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    105601165 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    105601165 (MAP2K1)
   04062 Chemokine signaling pathway
    105601165 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105601165 (MAP2K1)
   04929 GnRH secretion
    105601165 (MAP2K1)
   04912 GnRH signaling pathway
    105601165 (MAP2K1)
   04915 Estrogen signaling pathway
    105601165 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    105601165 (MAP2K1)
   04917 Prolactin signaling pathway
    105601165 (MAP2K1)
   04921 Oxytocin signaling pathway
    105601165 (MAP2K1)
   04926 Relaxin signaling pathway
    105601165 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    105601165 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    105601165 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    105601165 (MAP2K1)
   04916 Melanogenesis
    105601165 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105601165 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    105601165 (MAP2K1)
   04726 Serotonergic synapse
    105601165 (MAP2K1)
   04720 Long-term potentiation
    105601165 (MAP2K1)
   04730 Long-term depression
    105601165 (MAP2K1)
   04722 Neurotrophin signaling pathway
    105601165 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105601165 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105601165 (MAP2K1)
   05206 MicroRNAs in cancer
    105601165 (MAP2K1)
   05205 Proteoglycans in cancer
    105601165 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    105601165 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105601165 (MAP2K1)
   05230 Central carbon metabolism in cancer
    105601165 (MAP2K1)
   05231 Choline metabolism in cancer
    105601165 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105601165 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105601165 (MAP2K1)
   05212 Pancreatic cancer
    105601165 (MAP2K1)
   05225 Hepatocellular carcinoma
    105601165 (MAP2K1)
   05226 Gastric cancer
    105601165 (MAP2K1)
   05214 Glioma
    105601165 (MAP2K1)
   05216 Thyroid cancer
    105601165 (MAP2K1)
   05221 Acute myeloid leukemia
    105601165 (MAP2K1)
   05220 Chronic myeloid leukemia
    105601165 (MAP2K1)
   05218 Melanoma
    105601165 (MAP2K1)
   05211 Renal cell carcinoma
    105601165 (MAP2K1)
   05219 Bladder cancer
    105601165 (MAP2K1)
   05215 Prostate cancer
    105601165 (MAP2K1)
   05213 Endometrial cancer
    105601165 (MAP2K1)
   05224 Breast cancer
    105601165 (MAP2K1)
   05223 Non-small cell lung cancer
    105601165 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105601165 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    105601165 (MAP2K1)
   05161 Hepatitis B
    105601165 (MAP2K1)
   05160 Hepatitis C
    105601165 (MAP2K1)
   05164 Influenza A
    105601165 (MAP2K1)
   05163 Human cytomegalovirus infection
    105601165 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105601165 (MAP2K1)
   05165 Human papillomavirus infection
    105601165 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105601165 (MAP2K1)
   05135 Yersinia infection
    105601165 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105601165 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    105601165 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    105601165 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105601165 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105601165 (MAP2K1)
   01522 Endocrine resistance
    105601165 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:caty01001]
    105601165 (MAP2K1)
Enzymes [BR:caty01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     105601165 (MAP2K1)
Protein kinases [BR:caty01001]
 Serine/threonine kinases: STE group
  STE7 family
   105601165 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_fungal ABC1 Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 105601165
NCBI-ProteinID: XP_011948515
Ensembl: ENSCATG00000038127
LinkDB
Position
Unknown
AA seq 348 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKVSLPDGGSLDQVLKKAGRIPEQI
LGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVG
TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE
TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKN
PAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLHQPSTPTHAAGV
NT seq 1047 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttctcacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggccggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaaggtgagtttg
cctgatggaggttctctggatcaagtcctgaagaaagctggaagaattcctgaacaaatt
ttaggaaaagttagcattgctgtaataaaaggcctgacatatctgagggagaagcacaag
atcatgcacagagatgtcaagccctccaacatcctagtcaactcccgtggggagatcaag
ctctgtgactttggggtcagcgggcagctcatcgactccatggccaactccttcgtgggc
acaaggtcctacatgtcgccagaaagactccaggggactcattactctgtgcagtcagac
atctggagcatgggactctctctggtagagatggcggttgggaggtatcccatccctcct
ccagatgccaaggagctggaactgatgtttgggtgccaggtggagggagatgcggctgag
accccacctaggccaaggacccccgggaggccccttagctcatatggaatggacagccga
cctcccatggcaatttttgagttgttggattacatagtcaacgagcctcctccaaaattg
cccagtggagttttcagtctggaatttcaagattttgtgaataaatgcttaataaaaaac
cccgcagagagagcagatttgaagcaactcatggttcatgcttttatcaagagatctgat
gctgaggaagtggattttgcaggttggctctgctccactatcggccttcaccagcccagc
acaccaacccatgctgctggcgtctaa

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