KEGG   Cervus canadensis (wapiti): 122423529
Entry
122423529         CDS       T07554                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
ccad  Cervus canadensis (wapiti)
Pathway
ccad01522  Endocrine resistance
ccad04010  MAPK signaling pathway
ccad04015  Rap1 signaling pathway
ccad04068  FoxO signaling pathway
ccad04071  Sphingolipid signaling pathway
ccad04114  Oocyte meiosis
ccad04148  Efferocytosis
ccad04218  Cellular senescence
ccad04261  Adrenergic signaling in cardiomyocytes
ccad04370  VEGF signaling pathway
ccad04380  Osteoclast differentiation
ccad04550  Signaling pathways regulating pluripotency of stem cells
ccad04611  Platelet activation
ccad04613  Neutrophil extracellular trap formation
ccad04620  Toll-like receptor signaling pathway
ccad04621  NOD-like receptor signaling pathway
ccad04622  RIG-I-like receptor signaling pathway
ccad04625  C-type lectin receptor signaling pathway
ccad04657  IL-17 signaling pathway
ccad04658  Th1 and Th2 cell differentiation
ccad04659  Th17 cell differentiation
ccad04660  T cell receptor signaling pathway
ccad04664  Fc epsilon RI signaling pathway
ccad04668  TNF signaling pathway
ccad04670  Leukocyte transendothelial migration
ccad04714  Thermogenesis
ccad04722  Neurotrophin signaling pathway
ccad04723  Retrograde endocannabinoid signaling
ccad04728  Dopaminergic synapse
ccad04750  Inflammatory mediator regulation of TRP channels
ccad04912  GnRH signaling pathway
ccad04914  Progesterone-mediated oocyte maturation
ccad04917  Prolactin signaling pathway
ccad04926  Relaxin signaling pathway
ccad04932  Non-alcoholic fatty liver disease
ccad04933  AGE-RAGE signaling pathway in diabetic complications
ccad04935  Growth hormone synthesis, secretion and action
ccad04936  Alcoholic liver disease
ccad05014  Amyotrophic lateral sclerosis
ccad05020  Prion disease
ccad05022  Pathways of neurodegeneration - multiple diseases
ccad05132  Salmonella infection
ccad05133  Pertussis
ccad05135  Yersinia infection
ccad05140  Leishmaniasis
ccad05142  Chagas disease
ccad05145  Toxoplasmosis
ccad05152  Tuberculosis
ccad05161  Hepatitis B
ccad05163  Human cytomegalovirus infection
ccad05167  Kaposi sarcoma-associated herpesvirus infection
ccad05169  Epstein-Barr virus infection
ccad05170  Human immunodeficiency virus 1 infection
ccad05171  Coronavirus disease - COVID-19
ccad05205  Proteoglycans in cancer
ccad05208  Chemical carcinogenesis - reactive oxygen species
ccad05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ccad05415  Diabetic cardiomyopathy
ccad05417  Lipid and atherosclerosis
ccad05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ccad00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122423529 (MAPK12)
   04015 Rap1 signaling pathway
    122423529 (MAPK12)
   04370 VEGF signaling pathway
    122423529 (MAPK12)
   04668 TNF signaling pathway
    122423529 (MAPK12)
   04068 FoxO signaling pathway
    122423529 (MAPK12)
   04071 Sphingolipid signaling pathway
    122423529 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    122423529 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    122423529 (MAPK12)
   04218 Cellular senescence
    122423529 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    122423529 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122423529 (MAPK12)
   04613 Neutrophil extracellular trap formation
    122423529 (MAPK12)
   04620 Toll-like receptor signaling pathway
    122423529 (MAPK12)
   04621 NOD-like receptor signaling pathway
    122423529 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    122423529 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    122423529 (MAPK12)
   04660 T cell receptor signaling pathway
    122423529 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    122423529 (MAPK12)
   04659 Th17 cell differentiation
    122423529 (MAPK12)
   04657 IL-17 signaling pathway
    122423529 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    122423529 (MAPK12)
   04670 Leukocyte transendothelial migration
    122423529 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    122423529 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    122423529 (MAPK12)
   04917 Prolactin signaling pathway
    122423529 (MAPK12)
   04926 Relaxin signaling pathway
    122423529 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    122423529 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    122423529 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    122423529 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    122423529 (MAPK12)
   04722 Neurotrophin signaling pathway
    122423529 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122423529 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    122423529 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    122423529 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    122423529 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    122423529 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122423529 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122423529 (MAPK12)
   05161 Hepatitis B
    122423529 (MAPK12)
   05171 Coronavirus disease - COVID-19
    122423529 (MAPK12)
   05163 Human cytomegalovirus infection
    122423529 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122423529 (MAPK12)
   05169 Epstein-Barr virus infection
    122423529 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122423529 (MAPK12)
   05135 Yersinia infection
    122423529 (MAPK12)
   05133 Pertussis
    122423529 (MAPK12)
   05152 Tuberculosis
    122423529 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    122423529 (MAPK12)
   05140 Leishmaniasis
    122423529 (MAPK12)
   05142 Chagas disease
    122423529 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    122423529 (MAPK12)
   05020 Prion disease
    122423529 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    122423529 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122423529 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    122423529 (MAPK12)
   05415 Diabetic cardiomyopathy
    122423529 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    122423529 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    122423529 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122423529 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    122423529 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ccad01001]
    122423529 (MAPK12)
Enzymes [BR:ccad01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     122423529 (MAPK12)
Protein kinases [BR:ccad01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   122423529 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 122423529
NCBI-ProteinID: XP_043296636
LinkDB
Position
21:452781..460947
AA seq 367 aa
MSSPSPARKGFYRQEVTKTAWEVRVVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRVQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGKTLFKGNDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVSLLEKMLVLDAERRV
TAAEALAHPYFESLQDTEDEPQAQKYDESFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctccgtcgcccgcccgcaagggcttttatcgccaggaggtgaccaagacggcc
tgggaggtgcgcgtcgtgtaccaggatctgcaacccgtgggctcgggcgcctacggcgcc
gtgtgctcggcggtggacagccgcacgggcgccaaggttgccatcaagaagctgtaccgg
ccctttcagtccgagctgttcgccaagcgcgcctaccgcgagcttcgcctgctgaagcac
atgcgccacgagaacgtgattgggctgctggacgtgttcacgcccgacgagacgctggat
gacttcacggacttttacctggtgatgccgttcatgggcaccgacctgggaaagctcatg
aagcatgagaagctgagtgaggaccgagtgcagttccttgtctaccagatgctcaagggg
ctgaagtacatccacgctgctggcgtcatccacagggacctgaagcccggcaacctggcg
gtgaacgaggactgtgagctgaagatcctggacttcggcctggcccggcaggcagacagc
gagatgaccgggtacgtggtgaccaggtggtaccgggcgcccgaggtcatcttgaactgg
atgcactacacgcagacggtggacatctggtccgtgggctgcatcatggccgagatgatc
acggggaagacgctcttcaaaggcaacgaccacctggaccagctgaaggagatcatgaag
gtgacggggacgcctccagcggagtttgtgcagaggctgcaaagtgacgaggccaagaac
tacatgaagggcctccctgagctggagaagaaggattttgcctccatcctgaccaacgcg
agccccctggccgtgagcctcctggagaagatgctggtgctggacgcggagcggcgggtg
acggcggccgaggcgctggcccacccctacttcgagtcgctgcaggacacggaggacgag
ccccaggcccagaagtacgacgagtccttcgatgacgtggaccgcacgctggacgagtgg
aagcgtgtcacatataaagaggtgctcagcttcaagcctccccggcagctgggggccaag
gtctccaaggagacagccttgtga

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