Cervus canadensis (wapiti): 122435189
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Entry
122435189 CDS
T07554
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like isoform X1
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
ccad
Cervus canadensis (wapiti)
Pathway
ccad00010
Glycolysis / Gluconeogenesis
ccad00020
Citrate cycle (TCA cycle)
ccad00620
Pyruvate metabolism
ccad00785
Lipoic acid metabolism
ccad01100
Metabolic pathways
ccad01200
Carbon metabolism
ccad01210
2-Oxocarboxylic acid metabolism
ccad04066
HIF-1 signaling pathway
ccad04922
Glucagon signaling pathway
ccad05230
Central carbon metabolism in cancer
ccad05415
Diabetic cardiomyopathy
Module
ccad_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
ccad00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
122435189
00020 Citrate cycle (TCA cycle)
122435189
00620 Pyruvate metabolism
122435189
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
122435189
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
122435189
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
122435189
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
122435189
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
122435189
Enzymes [BR:
ccad01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
122435189
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Motif
Pfam:
E1_dh
DXP_synthase_N
Motif
Other DBs
NCBI-GeneID:
122435189
NCBI-ProteinID:
XP_043315094
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Position
X:90661045..90662304
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AA seq
391 aa
AA seq
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MKKMLTAAVSRVLSGVTQKPASRVLAASCKYSNNATFEIKKCDLYRLEEGPPVTTVLTRE
DGLKYYKMMQTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPTDHVITSYR
AHGFSYTRGLTVRSILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQGPLGAGVAL
ACKYEGNNEVCLTLYGDGAANQGQISEAYNMAALWNLPCIFICENNRYGMGTSLERAAAN
TDYYKRGNFIPGLRVDGMDILCVREATKFAADYCRSGKGPILMELLTYRYHGHSMSDPGI
SYRTREEIQSVRSKSDPIMLLKDKMVNNKLASVEELKEIDVEVRKEIDDAAQFAMTDPEP
PLEELGHHIYSSNPPFDIRGANQWIKFQSIS
NT seq
1176 nt
NT seq
+upstream
nt +downstream
nt
atgaagaagatgctgaccgcggctgtctctcgcgtgctgtctggcgtcacccagaagccc
gctagcagagtgcttgcagcctcctgtaaatattcaaacaatgctacctttgagattaag
aaatgtgatctttatcggttggaagagggtccgcccgtcaccaccgtgctcacccgggag
gatggactcaaatactacaagatgatgcagacggttcgtcgaatggaactgaaggcagat
cagttgtataaacagaaatttattcgtggtttctgtcacttgtgtgatggtcaggaagct
tgttgtgtgggtcttgaggctgggataaatcccacggatcacgtcattacgtcctatcgg
gctcacggcttcagttatacgcggggacttactgtccgatcaattctggcagagctgaca
ggacgaagagggggttgtgctaaaggaaagggagggtccatgcatatgtatgccaagaac
ttctatgggggcaatggcattgtcggcgctcagggaccactgggagccggtgttgctctg
gcctgtaaatacgaggggaacaacgaggtgtgtttgactctgtatggcgatggcgctgct
aatcagggtcagatatctgaagcttacaatatggcggctttgtggaatttaccttgcatt
ttcatctgtgagaataaccgctatggaatgggaacatctttggagagagccgcagccaat
actgattactacaagagaggcaattttatccctggtctaagagtagatggaatggatatt
ctatgtgttcgggaggcaactaagtttgcagctgactattgtagatctggaaaggggccc
atactgatggagctgctgacataccgttatcatggacacagtatgagtgatcctggaatc
agttaccgtacacgagaagaaattcagagtgtaagaagtaagagtgatcctattatgctt
ctcaaggataaaatggtaaacaacaagcttgccagtgttgaagaattgaaggaaattgat
gttgaagtgaggaaagaaattgatgatgcagctcaatttgctatgactgatccggaacca
cctttggaagaattaggccatcacatctacagcagtaatccaccttttgatattcgtggt
gcaaatcagtggatcaagtttcagtcaatcagttaa
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